EPHB2 / EPH Receptor B2 Antibody (HRP)
Primary AntibodyLSBio Guarantee
| Antibody: | Rabbit Polyclonal |
| Applications: | Enzyme-Linked Immunosorbent Assay |
| Reactivity: | Human |
| Format: | Liquid |
$300.00each
Catalog Number: LS-C498792-50
Catalog Number: LS-C498792
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- Description
- EPH Receptor B2 antibody LS-C498792 is an HRP-conjugated rabbit polyclonal antibody to human EPH Receptor B2 (EPHB2). Validated for ELISA.
- Application
- ELISA
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Polyclonal Antibodies
- Alternative Names
- CAPB | Cek5 | EK5 | ETECK | EPH tyrosine kinase 3 | EPHB2 | DRT | ELK-related tyrosine kinase | Hek5 | EPH-like kinase 5 | EPHT3 | Nuk | PCBC | Tyrosine-protein kinase TYRO5 | Protein-tyrosine kinase HEK5 | Tyro5 | EPH receptor B2 | Ephrin type-B receptor 2 | EPTH3
- UniProt Number
- P29323
- NCBI GenBank
- AAB94602.1 | NM_017449
- SwissProt
- P29323
Target
- Target
- Human EPHB2 / EPH Receptor B2
- Antigen Species
- Human
- Epitope
- Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor.
- Gene Name
- EPHB2
Antibody
- Host Species
- Rabbit
- Clonality
- Polyclonal
- Isotype
- IgG
Immunogen
- Immunogen
- Recombinant human Ephrin type-B receptor 2 protein (261-465AA)
- Immunogen Type
- Recombinant Immunogen
Format
- Conjugate/Label
- Horseradish Peroxidase
- Format
- Liquid
- Formulation
- PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
- Preservative
- Yes
- Purification Method
- Protein G Affinity
Storage & Handling
- Storage Conditions
- Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
- Recommended Storage Buffer
- PBS