Positive WB detected in:Mouse heart tissue,Mouse lung tissue,Mouse stomach tissue;All lanes: DMRT1 antibody at 3ug/ml;Secondary;Goat polyclonal to rabbit IgG at 1/50000 dilution;Predicted band size: 40,29,19 kDa;Observed band size: 40 kDa;

DMRT1 Antibody

Primary AntibodyLSBio Guarantee

Antibody:	Rabbit Polyclonal
Applications:	Enzyme-Linked Immunosorbent Assay, Immunohistochemistry (general), Western Blot
Reactivity:	Human, Mouse
Format:	Liquid

$300.00each

Catalog Number: LS-C502226-50

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Overview

Description: DMRT1 antibody LS-C502226 is an unconjugated rabbit polyclonal antibody to DMRT1 from human. It is reactive with human and mouse. Validated for ELISA, IHC and WB.
Application: ELISA, IHC, WB
Reactivity: Hu, Ms
Intended Use: Research Use Only
Guarantees: This antibody carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names: DMRT1 | DMT1
UniProt Number: Q9Y5R6
NCBI GenBank: NM_021951 | NP_068770.2
SwissProt: Q9Y5R6

Target

Target: Human DMRT1
Antigen Species: Human
Epitope: Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity).
Gene Name: DMRT1