Complement C5 Antibody
Catalog Number: LS-C140221-100
100 µg / $601.00
Antibody: Rabbit Polyclonal
Applications: Immunohistochemistry (general), Western Blot
Reactivity: Mouse
Format: Liquid
Complement C5 Antibody (N-Terminus, clone 046-10.2.2 (10-04))
Primary AntibodyLSBio Guarantee
| Antibody: | Mouse Monoclonal |
| Applications: | Enzyme-Linked Immunosorbent Assay, Immunohistochemistry (general), Western Blot |
| Reactivity: | Human |
| Format: | Liquid |
$489.00each
Catalog Number: LS-C44979-0.1
Catalog Number: LS-C44979
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- Description
- Complement C5 antibody LS-C44979 is an unconjugated mouse monoclonal antibody to human Complement C5 (N-Terminus). Validated for ELISA and WB.
- Application
- ELISA, IHC, WB
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Monoclonal Antibodies
- Alternative Names
- Anaphylatoxin C5a analog | C5 | CPAMD4 | Complement C5 | Complement component 5
- UniProt Number
- P01031
- NCBI GenBank
- NM_001735 | NP_001726.2
- SwissProt
- P01031
Target
- Target
- Human Complement C5
- Antigen Species
- Human
- Epitope
- Recognizes secreted complement component 5 (C5), a 190kD serine protease present in blood serum. It is composed of an 115kD disulphide linked alpha-chain and a 75 kD beta-chain. In addition to its role in complement, C5 is thought to be associated with inflammation, stimulating tumor necrosis factor alpha, interferon gamma mediated suppression of IL10 and IL12 production. C5 is activated via either the classical or the alternative complement pathway, by proteolytic cleavage of C5a from the N-terminal of the alpha-chain, by C5 convertase. C5a is an anaphylatoxin which mediates local inflammation. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. It also stimulates chemotaxis of neutrophils, eosinophils, basophils and monocytes towards the site of inflammation. The remaining fragment, C5b, initiates the assembly of the membrane attack complex. In hemolysis inhibition studies it was found that Will block C5 hemolytic activity. Removal of sodium azide is recommended prior to use in functional assays. XXX XXX recommend the use of EUQOO3 for this purpose.
- Gene Name
- C5
Antibody
- Host Species
- Mouse
- Clonality
- Monoclonal
- Clone
- 046-10.2.2 (10-04)
- Isotype
- IgG1
Immunogen
- Immunogen
- Purified human C5.
- Immunogen Type
- Native Protein (Purified from Natural Source)
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- BBS, 0.1% Sodium Azide
- Concentration
- 1.08 mg/mL
- Preservative
- Yes
- Purification Method
- Protein A Affinity
Storage & Handling
- Storage Conditions
- Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
- Recommended Storage Buffer
- bbs
