LSBio
Complement C3 / C3b Antibody (clone 013III-1.16)

Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)

Complement C3 / C3b Antibody (clone 013III-1.16)

Primary AntibodyLSBio Guarantee
Antibody:Mouse Monoclonal
Applications:Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunohistochemistry (general), Immunohistochemistry, Frozen, Immunohistochemistry, Paraffin, Western Blot
Reactivity:Human
Format:Liquid
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$733.00each
Catalog Number: LS-C44976-0.1

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Overview

Description
C3b antibody LS-C44976 is an unconjugated mouse monoclonal antibody to human C3b (Complement C3). Validated for ELISA, Flow, IHC and WB.
Application
ELISA, FC, IHC, IHC-F, IHC-P, WB
Reactivity
Hu
Intended Use
Research Use Only
Guarantees
This antibody carries the LSBio 100% Guarantee. ✓
Category
Antibodies > Primary Antibodies > Monoclonal Antibodies
Alternative Names
Breast Epithelial Mucin | BEM
Recommended Dilution: IHC-P
10 µg/ml

Target

Target
Human Complement C3 / C3b
Antigen Species
Human
Epitope
Recognizes 42kD human inactive complement component 3b (iC3b) neoantigen present in blood serum. Cleavage of C3b into iC3b by the protease factor I, in the presence of cofactors, changes the structure and resulting binding properties, preventing binding by complement factor B and properdin. This prevents further progression of the complement pathway, providing another mechanism by which the complement pathway may be regulated. iC3b is thought to play a role in inducing tolerance, binding complement receptor type 3 on antigen presenting cells and stimulating them to produce transforming growth factor beta2 and interleukin-10. It is thought to stimulate B-cells via the CD21 receptor providing a link between the innate and adaptive immune responses. Additionally iC3b acts as an opsonin which is recognized by complement receptor 3 expressed on leukocytes or complement receptor of the immunoglobulin superfamily (CRIg) on Kupffer cells, stimulating phagocytosis of the tagged cells. iC3b levels are often elevated in diseases such as Systemic Lupus Erythematosus and Rheumatoid arthritis.

Antibody

Host Species
Mouse
Clonality
Monoclonal
Clone
013III-1.16
Isotype
IgG2b

Immunogen

Immunogen
Purified human iC3b.
Immunogen Type
Native Protein (Purified from Natural Source)

Format

Conjugate/Label
Unconjugated
Format
Liquid
Formulation
BBS, 0.09% Sodium Azide
Concentration
1.045 mg/mL
Preservative
Yes
Purification Method
Protein A Affinity

Storage & Handling

Storage Conditions
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
Recommended Storage Buffer
bbs

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To request an SDS/MSDS form for this product, please contact our Technical Support department at: technical@vectorlabs.com.