CFH / Complement Factor H Antibody (clone 10-10)
Primary AntibodyLSBio Guarantee
| Antibody: | Mouse Monoclonal |
| Applications: | Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunohistochemistry, Frozen, Western Blot |
| Reactivity: | Human |
| Format: | Liquid |
$540.00each
Catalog Number: LS-C44982-0.1
Catalog Number: LS-C44982
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- Description
- Complement Factor H antibody LS-C44982 is an unconjugated mouse monoclonal antibody to human Complement Factor H (CFH). Validated for ELISA, Flow, IHC and WB.
- Application
- ELISA, FC, IHC-F, WB
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Monoclonal Antibodies
- Alternative Names
- Adrenomedullin binding protein | AHUS1 | AMBP1 | ARMS1 | ARMD4 | Beta-1-H-globulin | CFH | Factor H | Factor H-like 1 | HF | HF2 | H factor 1 | H factor 2 (complement) | HUS | HF1 | Beta-1H | CFHL3 | Complement factor H | H factor 1 (complement)
- UniProt Number
- P08603
- NCBI GenBank
- NM_000186 | NP_000177.2
- SwissProt
- P08603
Target
- Target
- Human CFH / Complement Factor H
- Antigen Species
- Human
- Epitope
- Recognizes human complement factor H which exists in 2 forms. The most common form, of 150 kD, and the less common form of 43 kD. Factor H is secreted by the liver into the blood serum. It is important in regulating the complement pathway, preventing unnecessary inflammation which can damage the host tissue. Factor H functions as a cofactor in the inactivation of C3b by factor I. It makes C3b susceptible to cleavage by factor I, resulting in iC3b. Factor H also inhibits the formation of the C3bBb complex (C3 convertase) and increases the rate of dissociation of both C3 convertase and the (C3b)NBB complex (C5 convertase). This prevents these components of the classical and of alternative complement pathways from forming a positive feedback loop. Mutations in factor H are associated with hemolytic-uremic syndrome, age-related macular degeneration, membranoproliferative glomerulonephritis (MPGN) type II and chronic hypocomplementemic nephropathy.
- Gene Name
- CFH
Antibody
- Host Species
- Mouse
- Clonality
- Monoclonal
- Clone
- 10-10
- Isotype
- IgG1
Immunogen
- Immunogen
- Purified human factor H from serum.
- Immunogen Type
- Native Protein (Purified from Natural Source)
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- BBS, 0.1% Sodium Azide
- Concentration
- 1 mg/mL
- Preservative
- Yes
- Purification Method
- Protein A Affinity
Storage & Handling
- Storage Conditions
- Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
- Recommended Storage Buffer
- bbs