Formalin-paraffin human Melanoma stained with CD63 Recombinant Mouse Monoclonal Antibody (rMX-49.129.5).

CD63 Antibody (clone rMX-49.129.5, Azide-free, Carrier-free)

Primary AntibodyLSBio Guarantee

Antibody:	Mouse Recombinant Monoclonal
Applications:	Immunohistochemistry, Paraffin
Reactivity:	Human
Format:	Liquid

$586.00each

Catalog Number: LS-C751479-100

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Overview

Description: CD63 antibody LS-C751479 is an unconjugated mouse recombinant monoclonal antibody to human CD63. Validated for IHC.
Application: IHC-P
Reactivity: Hu
Intended Use: Research Use Only
Guarantees: This antibody carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Recombinant Antibodies
Alternative Names: CD63 molecule | LAMP-3 | ME491 | Granulophysin | MLA1 | Tetraspanin-30 | Tspan-30 | CD63 | CD63 antigen | OMA81H | TSPAN30
Recommended Dilution: IHC-P: 1 - 2 µg/ml
UniProt Number: P08962
NCBI GenBank: NM_001780 | NP_001771.1
SwissProt: P08962

Target

Target: Human CD63
Antigen Species: Human
Epitope: This MAb recognizes protein of 26 kDa -60 kDa , which is identified as CD63. Its epitope is different from that of MAb LAMP3/529. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. CD63 deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression.
Gene Name: CD63

Antibody

Host Species: Mouse
Clonality: Recombinant Monoclonal
Clone: rMX-49.129.5
Isotype: IgG1
Light Chain: Kappa Light Chain
Origin Species: Human

Immunogen

Immunogen: Smooth plasma membrane fraction of MeWo cells. Antigen Molecular Weight: 26 kDa (core protein) - 30-60 kDa (glycosylated)
Immunogen Type: Tissue Extract