Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with CD59 Rabbit Recombinant Monoclonal Antibody (MACIF/2867R).

CD59 Antibody (clone MACIF/2867R, Azide-free, Carrier-free)

Primary AntibodyLSBio Guarantee

Antibody:	Rabbit Recombinant Monoclonal
Applications:	Immunohistochemistry, Paraffin
Reactivity:	Human
Format:	Liquid

$586.00each

Catalog Number: LS-C751477-100

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Overview

Description: CD59 antibody LS-C751477 is an unconjugated rabbit recombinant monoclonal antibody to human CD59. Validated for IHC.
Application: IHC-P
Reactivity: Hu
Nonreactive Species: Horse, Non-Human Primate
Intended Use: Research Use Only
Guarantees: This antibody carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Recombinant Antibodies
Alternative Names: 16.3A5 | 1F5 | 1F5 antigen | CD59 glycoprotein | EL32 | EJ16 | G344 | HRF-20 | MAC-IP | MACIF | Ly-6-like protein | MEM43 | MIRL | MEM43 antigen | MIN2 | MIN3 | MSK21 | p18-20 | Protectin | MAC-inhibitory protein | MIC11 | T cell-activating protein | CD59 | CD59 antigen | EJ30 | HRF20 | Human leukocyte antigen MIC11 | Lymphocytic antigen CD59/MEM43 | MIN1
Recommended Dilution: IHC-P: 1 - 2 µg/ml
UniProt Number: P13987
NCBI GenBank: NM_000611 | NP_000602.1
SwissProt: P13987

Target

Target: Human CD59
Antigen Species: Human
Epitope: Reacts with human CD59, a 20 kDa glycosyl phosphatidyl-inositol (GPI)-anchored cell surface protein (Workshop VI; Code N-L036). CD59 regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. CD59 is widely distributed on cells in all tissues. It inhibits formation of MAC, thus protecting cells from complement-mediated lysis. The expression of CD59 on erythrocytes is important for their survival. Genetic defects in GPI-anchor attachment, that cause a reduction or loss of CD59 and CD55 on erythrocytes produce the symptoms of the disease paroxysmal hemoglobinuria (PNH). This MAb recognizes CD59 transfected cells. It is useful for study on GPI-anchored proteins, PNH and CD59 functions.
Gene Name: CD59