CD45 / LCA Antibody (clone UM16-6)
Primary AntibodyLSBio Guarantee
| Antibody: | Mouse Monoclonal |
| Applications: | Flow Cytometry, Immunohistochemistry, Frozen, Immunoprecipitation |
| Reactivity: | Chicken |
| Format: | Liquid |
$309.00each
Catalog Number: LS-C187495-0.1
Catalog Number: LS-C187495
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- Description
- LCA antibody LS-C187495 is an unconjugated mouse monoclonal antibody to chicken LCA (CD45). Validated for Flow, IHC and IP.
- Application
- FC, IHC-F, IP
- Reactivity
- Ck
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Monoclonal Antibodies
- Alternative Names
- B220 | CD45R | CD45 | gp180 | Leukocyte common antigen | L-CA | Leucocyte common antigen | LY5 | T200 | T200 glycoprotein | T200 leukocyte common antigen | CD45 antigen | LCA | PTPRC
- UniProt Number
- P08575
- NCBI GenBank
- NM_002838 | NP_002829.3
- SwissProt
- P08575
Target
- Target
- Chicken CD45 / LCA
- Antigen Species
- Chicken
- Epitope
- Clone UM16-6 recognizes chicken CD45 (leucocyte common antigen), a heavily-glycosylated transmembrane protein tyrosine phosphatase (PTPase) expressed by all nucleated cells of hematopoietic origin. Variation in the expression of a particular CD45 isoform is regulated during the hematopoietic development of the different cell lineages. CD45 is essential for antigen-induced signal transduction through the antigen receptor and as with other PTPase family members, acts in balance with protein tyrosine kinases, causing the dephosphorylation of negative regulatory tyrosine sites. Studies have indicated that dephosphorylation by CD45 is required for the activation of the src-family kinases p56lck and p59fyn. Investigations into the properties of CD45 in chicken models are limited, but there is evidence of the existence of an additional cysteine residue near the transmembrane region. The overall domain structure between mammalian and chicken CD45 appears to be conserved, but the sequence homology between the extracellular regions is very low.
- Gene Name
- PTPRC
Antibody
- Host Species
- Mouse
- Clonality
- Monoclonal
- Clone
- UM16-6
- Isotype
- IgG2a
Immunogen
- Immunogen
- COS cells transfected with CD45 gene.
- Immunogen Type
- Cell-Based Immunization
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS, 0.09% Sodium Azide
- Concentration
- 1 mg/mL
- Preservative
- Yes
- Purification Method
- Protein G Affinity
Storage & Handling
- Storage Conditions
- Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
- Recommended Storage Buffer
- PBS