Western blot analysis of extracts of various cell lines.
CCNH / Cyclin H Antibody
| Antibody: | Rabbit Polyclonal |
| Applications: | Immunofluorescence, Immunohistochemistry (general), Immunoprecipitation, Western Blot |
| Reactivity: | Human |
| Format: | Liquid |
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- Description
- Cyclin H antibody LS-C331195 is an unconjugated rabbit polyclonal antibody to human Cyclin H (CCNH). Validated for IF, IP and WB. Cited in 3 publications.
- Application
- IF, IHC, IP, WB
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Polyclonal Antibodies
- Alternative Names
- Cyclin H | p34 | p37 | CAK | CAK complex subunit | CCNH | Cyclin-H | MO15-associated protein
- Recommended Dilution: IP
- 1:50 - 1:200
- Recommended Dilution: WB
- 1:500 - 1:2000
- UniProt Number
- P51946
- NCBI GenBank
- NM_001239 | NP_001230.1
- SwissProt
- P51946
Target
- Target
- Human CCNH / Cyclin H
- Antigen Species
- Human
- Epitope
- Human CCNH / Cyclin H
- Gene Name
- CCNH
Antibody
- Host Species
- Rabbit
- Clonality
- Polyclonal
- Isotype
- IgG
Immunogen
- Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human CCNH (NP_001230.1). MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL
- Immunogen Type
- Fusion Protein (e.g., GST, MBP tag)
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS, pH 7.3, 0.02% Sodium Azide, 50% Glycerol
- Concentration
- 2.42 mg/mL
- Volume
- 20 Microliter
- Preservative
- Yes
- Purification Method
- Affinity Purified
Storage & Handling
- Storage Conditions
- Store at -20°C. Avoid freeze-thaw cycles.
- Recommended Storage Buffer
- PBS
Cyclins B1, T1, and H differ in their molecular mode of interaction with cytomegalovirus protein kinase pUL97. Steingruber M, Keller L, Socher E, Ferre S, Hesse AM, Couté Y, Hahn F, Büscher N, Plachter B, Sticht H, Marschall M. The Journal of biological chemistry. 2019 April;294:6188-6203.
PubMed: 30782840 · PMC: PMC6463711
Functional Relevance of the Interaction between Human Cyclins and the Cytomegalovirus-Encoded CDK-Like Protein Kinase pUL97. Martin Schütz, Mirjam Steingruber, Eileen Socher , Regina Müller, Sabrina Wagner, Merle Kögel, Heinrich Sticht, Manfred Marschall. Viruses. 2021 Jun;13:1248.
PubMed: 34198986 · PMC: PMC8310212
Highly Conserved Interaction Profiles between Clinically Relevant Mutants of the Cytomegalovirus CDK-like Kinase pUL97 and Human Cyclins: Functional Significance of Cyclin H. Martin Schütz, Regina Müller, Eileen Socher, Christina Wangen, Florian Full, Emanuel Wyler, Diana Wong, Myriam Scherer, Thomas Stamminger, Sunwen Chou, William D Rawlinson, Stuart T Hamilton, Heinrich Sticht, Manfred Marschall. International journal of molecular sciences. 2022 October;23.
PubMed: 36233116 · PMC: PMC9569496