LSBio
C5b-9 Terminal Complement Complex / TCC Antibody (clone 3R2/0)

C5b-9 Terminal Complement Complex / TCC Antibody (clone 3R2/0)

Primary AntibodyLSBio Guarantee
Antibody:Mouse Monoclonal
Applications:Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunohistochemistry (general), Immunohistochemistry, Frozen, Western Blot
Reactivity:Human
Format:Liquid
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$839.00each
Catalog Number: LS-C58185-0.1

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Overview

Description
TCC antibody LS-C58185 is an unconjugated mouse monoclonal antibody to human TCC (C5b-9 Terminal Complement Complex). Validated for ELISA, Flow, IHC and WB.
Application
ELISA, FC, IHC, IHC-F, WB
Reactivity
Hu
Intended Use
Research Use Only
Guarantees
This antibody carries the LSBio 100% Guarantee. ✓
Category
Antibodies > Primary Antibodies > Monoclonal Antibodies

Target

Target
Human C5b-9 Terminal Complement Complex / TCC
Antigen Species
Human
Epitope
Recognizes the SC5b-9 complex of around 330 kD. Both the classical and alternative complement pathways result in the formation of the cytolysis inducing C5b-9 complex. This complex is composed of 190 kD C5b which is bound to cells via 71 kD C9. Sublytic assembly of C5b-9 on plasma membranes induces cell cycle activation and survival. The binding of C5b-9 to the 75 kD S-protein (or vitronectin) in the fluid phase prevents C5b-9 from assembling on the plasma membrane, deactivating it and forming the SC5b-9 complex. SC5b-9 is stable in vitro and is therefore a reliable indicator of terminal complement pathway activation. Removal of Sodium Azide is recommended prior to use in functional assays. Reported to work in western blotting applications.

Antibody

Host Species
Mouse
Clonality
Monoclonal
Clone
3R2/0
Isotype
IgG2a

Format

Conjugate/Label
Unconjugated
Format
Liquid
Formulation
BBS, 0.1% Sodium Azide
Concentration
1 mg/mL
Preservative
Yes
Purification Method
Affinity Purified

Storage & Handling

Storage Conditions
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
Recommended Storage Buffer
bbs

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