LSBio
C/EBP Beta / CEBPB Antibody

Immunohistochemistry of paraffin-embedded human lung tissue using CEBPB Antibody at dilution of 1:100

C/EBP Beta / CEBPB Antibody

Primary AntibodyLSBio Guarantee
Antibody:Rabbit Polyclonal
Applications:Enzyme-Linked Immunosorbent Assay, Immunohistochemistry (general)
Reactivity:Human
Format:Liquid
See all Human C/EBP Beta / CEBPB antibodies →
$300.00each
Catalog Number: LS-C498596-50

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Overview

Description
CEBPB antibody LS-C498596 is an unconjugated rabbit polyclonal antibody to human CEBPB (C / EBP Beta). Validated for ELISA and IHC.
Application
ELISA, IHC
Reactivity
Hu
Intended Use
Research Use Only
Guarantees
This antibody carries the LSBio 100% Guarantee. ✓
Category
Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names
C/EBP-beta | C/EBP beta | CEBPB | CRP2 | LAP | Liver activator protein | Nuclear factor NF-IL6 | IL6DBP | TCF5 | NFIL6 | TCF-5 | Transcription factor 5 | NF-IL6
UniProt Number
P17676
NCBI GenBank
NM_005194 | NP_005185.2
SwissProt
P17676

Target

Target
Human C/EBP Beta / CEBPB
Antigen Species
Human
Epitope
Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:9374525, PubMed:12048245, PubMed:18647749). Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Plays also a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis (By similarity).
Gene Name
CEBPB

Antibody

Host Species
Rabbit
Clonality
Polyclonal
Isotype
IgG

Immunogen

Immunogen
Recombinant Human CCAAT/enhancer-binding protein beta protein (41-270AA)
Immunogen Type
Recombinant Immunogen

Format

Conjugate/Label
Unconjugated
Format
Liquid
Formulation
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Preservative
Yes
Purification Method
Protein G Affinity

Storage & Handling

Storage Conditions
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
Recommended Storage Buffer
PBS

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