LSBio
BRCA1 Antibody (aa762-1315)

BRCA1 Antibody (aa762-1315)

Primary AntibodyLSBio Guarantee
Antibody:Mouse Monoclonal
Applications:Immunohistochemistry (general), Immunoprecipitation, Western Blot
Reactivity:Human
Format:Liquid
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$575.00each
Catalog Number: LS-C83427-100

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Overview

Description
BRCA1 antibody LS-C83427 is an unconjugated mouse monoclonal antibody to human BRCA1 (aa762-1315). Validated for IHC, IP and WB.
Application
IHC, IP, WB
Reactivity
Hu
Intended Use
Research Use Only
Guarantees
This antibody carries the LSBio 100% Guarantee. ✓
Category
Antibodies > Primary Antibodies > Monoclonal Antibodies
Alternative Names
BRCA1 | BROVCA1 | BRCC1 | Breast cancer 1, early onset | PPP1R53 | PSCP | PNCA4 | RING finger protein 53 | RNF53 | BRCAI | Breast cancer 1 early onset | IRIS
Recommended Dilution: IHC
1 - 10 ug/ml
UniProt Number
P38398
NCBI GenBank
NM_007294 | NP_009225.1
SwissProt
P38398

Target

Target
Human BRCA1
Antigen Species
Human
Epitope
Recognizes full-length BRCA1, a 220 kD nuclear phosphoprotein, and does not recognize the ~exon 11 splice variant. In a high proportion of breast and ovarian cancer cell lines, BRCA1 aberrantly mislocates to the cytoplasm. Its usefulness to monitor functional inactivation of BRCA1 in sporadic breast cancers is under active investigation.
Gene Name
BRCA1

Antibody

Host Species
Mouse
Clonality
Monoclonal
Isotype
IgG1
Origin Species
Human

Immunogen

Immunogen
GST fusion protein expressed in E. coli corresponding to aa 762-1315 of full-length BRCA1.
Immunogen Type
Fusion Protein (e.g., GST, MBP tag)

Format

Conjugate/Label
Unconjugated
Format
Liquid
Formulation
PBS, pH 7.4
Preservative
No
Purification Method
Protein G Affinity

Storage & Handling

Storage Conditions
Short term: store at 4°C. Long term: aliquot and store at -20°C. Avoid freeze-thaw cycles.
Recommended Storage Buffer
PBS

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