BECN1 / Beclin-1 Antibody (Ser15)
Primary AntibodyLSBio Guarantee
| Antibody: | Rabbit Polyclonal |
| Applications: | Enzyme-Linked Immunosorbent Assay, Immunoprecipitation, Western Blot |
| Reactivity: | Human, Mouse |
| Format: | Liquid |
$485.00each
Catalog Number: LS-C415526-0.1
Catalog Number: LS-C415526
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- Description
- Beclin-1 antibody LS-C415526 is an unconjugated rabbit polyclonal antibody to Beclin-1 (BECN1) (Ser15) from human. It is reactive with human and mouse. Validated for ELISA, IP and WB.
- Application
- ELISA, IP, WB
- Reactivity
- Hu, Ms
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Polyclonal Antibodies
- Alternative Names
- ATG6 | Beclin 1 | Beclin 1, autophagy related | Beclin1 | GT197 | Protein GT197 | VPS30 | Beclin-1 | BECN1
- Recommended Dilution: ELISA
- 1:500 - 1:2000
- Recommended Dilution: IP
- 1:100 - 1:200
- Recommended Dilution: WB
- 1:100 - 1:1000
- UniProt Number
- Q14457
- NCBI GenBank
- NM_003766 | NP_003757.1
- SwissProt
- Q14457
Target
- Target
- Human BECN1 / Beclin-1
- Antigen Species
- Human
- Epitope
- Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. Beclin-1, a coiled-coil Bcl-2-interacting protein homologous to the yeast autophagy gene apg6, is a mammalian autophagy gene that can inhibit tumorigenesis and is expressed at reduced levels in human breast carcinoma, suggesting that defects in autophagy proteins may contribute to the development or progression of tumors. Bcl-2 can bind to Beclin-1 and inhibit Beclin-1-dependent autophagy in yeast and mammalian cells, suggesting that Bcl-2 functions as an anti-autophagy protein as well as an anti-apoptotic protein, which helps maintain autophagy at levels that are more compatible with cell survival rather than cell death. ULK1 protein kinase and the VPS34 lipid kinase are key regulators of autophagy initiation and progression. Activated during low nutrient conditions, ULK1 directly phosphorylates Beclin-1 at multiple sites including Ser15.
- Gene Name
- BECN1
Antibody
- Host Species
- Rabbit
- Clonality
- Polyclonal
Immunogen
- Immunogen
- KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser15 of human beclin-1.
- Immunogen Type
- Synthetic Peptide (Linear)
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS, pH 7.4, 0.1% BSA, 20% glycerol.
- Volume
- 0.1 Milliliter
- Preservative
- No
- Purification Method
- Affinity Purified
Storage & Handling
- Storage Conditions
- Store at -20°C. Avoid freeze-thaw cycles.
- Recommended Storage Buffer
- PBS