Formalin-fixed, paraffin-embedded human Tonsil stained with BCL-6 Mouse Recombinant Monoclonal Antibody (rBCL6/1718).

BCL6 Antibody (aa256-389, clone rBCL6/1718)

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Antibody:	Mouse Recombinant Monoclonal
Applications:	Immunohistochemistry, Paraffin
Reactivity:	Human
Format:	Liquid

$379.00each

Catalog Number: LS-C751348-20

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Description: BCL6 antibody LS-C751348 is an unconjugated mouse recombinant monoclonal antibody to human BCL6 (aa256-389). Validated for IHC.
Application: IHC-P
Reactivity: Hu
Intended Use: Research Use Only
Guarantees: This antibody carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Recombinant Antibodies
Alternative Names: BCL6A | BCL-5 | BCL5 | BCL6 | Protein LAZ-3 | LAZ3 | ZBTB27 | ZNF51 | B-cell CLL/lymphoma 6 | B-cell lymphoma 5 protein | B-cell lymphoma 6 protein | BCL-6 | Zinc finger protein 51
Recommended Dilution: IHC-P: 1 - 2 µg/ml
UniProt Number: P41182
NCBI GenBank: NM_001706 | NP_001697.2
SwissProt: P41182

Target: Human BCL6
Antigen Species: Human
Epitope: Recognizes a protein of 95 kDa , which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large ( L&H ) cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.
Gene Name: BCL6