LSBio
ATRX Antibody (clone ATRX/2900R)

Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with ATRX Rabbit Recombinant Monoclonal Antibody (ATRX/2900R).

ATRX Antibody (clone ATRX/2900R)

Primary AntibodyLSBio Guarantee
Antibody:Rabbit Recombinant Monoclonal
Applications:Immunohistochemistry, Paraffin
Reactivity:Human
Format:Liquid
See all Human ATRX antibodies →
$379.00each
Catalog Number: LS-C751314-20

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Overview

Description
ATRX antibody LS-C751314 is an unconjugated rabbit recombinant monoclonal antibody to human ATRX. Validated for IHC.
Application
IHC-P
Reactivity
Hu
Intended Use
Research Use Only
Guarantees
This antibody carries the LSBio 100% Guarantee. ✓
Category
Antibodies > Primary Antibodies > Recombinant Antibodies
Alternative Names
ATP-dependent helicase ATRX | ATR2 | Juberg-Marsidi syndrome | JMS | RAD54 | RAD54 homolog | SFM1 | MRXHF1 | XH2 | XNP | Transcriptional regulator ATRX | ZNF-HX | X-linked nuclear protein | SHS | ATRX | Helicase 2, X-linked | X-linked helicase II | Zinc finger helicase
Recommended Dilution: IHC-P
1 - 2 µg/ml
UniProt Number
P46100
NCBI GenBank
NM_000489 | NP_000480.3
SwissProt
P46100

Target

Target
Human ATRX
Antigen Species
Human
Epitope
ATRX is a member of the Snf2 family of helicase/ATPases, which contribute to the remodeling of the nucelosome structure in an ATP-dependent manner, and facilitate the initiation of transcription and replication. Structurally, ATRX contains a PHD zinc finger motif. ATRX is regulated throughout the cell cycle where it is differentially distributed within the nucleus. During interphase, ATRX predominately associates with the nuclear matrix, while during mitosis, ATRX localizes with condensed chromatin. At the onset of M phase, phosphorylation rapidly induces this redistribution of ATRX to the short arms of human acrocentric chromosomes, where it then specifically complexes with heterochromatin protein 1 alpha to mediate chromosomal segregation. Mutations in the ATRX gene correlate with a high incidence of severe X-linked form of syndromal mental retardation associated with alpha thalassemia or ATRX syndrome
Gene Name
ATRX

Antibody

Host Species
Rabbit
Clonality
Recombinant Monoclonal
Clone
ATRX/2900R
Isotype
IgG
Origin Species
Human

Immunogen

Immunogen
Recombinant full-length human ATRX protein. Antigen Molecular Weight: 280 kDa
Immunogen Type
Recombinant Immunogen

Format

Conjugate/Label
Unconjugated
Format
Liquid
Formulation
10 mM PBS, 0.05% BSA, 0.05% Sodium Azide
Concentration
200 µg/mL
Preservative
Yes
Purification Method
Protein A/G Affinity

Storage & Handling

Storage Conditions
Store at 2°C to 8°C for up to 2 years.
Recommended Storage Buffer
10 mM PBS

Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at: technical@vectorlabs.com.