Positive WB detected in:HEK293 whole cell lysate,Hela whole cell lysate,Jurkat whole cell lysate,Mouse heart tissue,Mouse liver tissue,Mouse brain tissue;All lanes: ARIH2 antibody at 3ug/ml;Secondary;Goat polyclonal to rabbit IgG at 1/50000 dilution;Predicted band size: 43,36 kDa;Observed band size: 58 kDa;

ARIH2 Antibody

Primary AntibodyLSBio Guarantee

Antibody:	Rabbit Polyclonal
Applications:	Enzyme-Linked Immunosorbent Assay, Immunohistochemistry (general), Western Blot
Reactivity:	Human, Mouse
Format:	Liquid

$300.00each

Catalog Number: LS-C498422-50

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Overview

Description: ARIH2 antibody LS-C498422 is an unconjugated rabbit polyclonal antibody to ARIH2 from human. It is reactive with human and mouse. Validated for ELISA, IHC and WB.
Application: ELISA, IHC, WB
Reactivity: Hu, Ms
Intended Use: Research Use Only
Guarantees: This antibody carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names: Ariadne homolog 2 (Drosophila) | ARIH2 | ARI-2 | ARI2 | Protein ariadne-2 homolog | TRIAD1 | Triad1 protein | Ariadne (Drosophila) homolog 2
UniProt Number: O95376
NCBI GenBank: NM_006321 | NP_006312.1
SwissProt: O95376

Target

Target: Human ARIH2
Antigen Species: Human
Epitope: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Gene Name: ARIH2