APOE / Apolipoprotein E Antibody (clone WUE-4, Biotin)
Primary AntibodyLSBio Guarantee
| Antibody: | Mouse Monoclonal |
| Applications: | Enzyme-Linked Immunosorbent Assay, Western Blot |
| Reactivity: | Human |
| Format: | Liquid |
$519.00each
Catalog Number: LS-C188622-0.1
Catalog Number: LS-C188622
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- Description
- Apolipoprotein E antibody LS-C188622 is a biotin-conjugated mouse monoclonal antibody to human Apolipoprotein E (APOE). Validated for ELISA and WB.
- Application
- ELISA, WB
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Monoclonal Antibodies
- Alternative Names
- AD2 | Apo-E | APOE | Apolipoprotein E3 | Apolipoprotein E | LDLCQ5 | LPG
- UniProt Number
- P02649
- NCBI GenBank
- NM_000041 | NP_000032.1
- SwissProt
- P02649
Target
- Target
- Human APOE / Apolipoprotein E
- Antigen Species
- Human
- Epitope
- Recognizes an epitope within amino acids 140-160 of human apolipoprotein E (Apo-E), a major component of very low-density lipoproteins (VLDLs). Apo-E is the principle apolipoprotein in the central nervous system, and is secreted by most organs into the plasma, playing a vital role in the binding, internalization and catabolism of triglyceride-rich lipoprotein constituents. Apo-E acts as a ligand for both the specific apo-E receptor (chylomicron remnant) of hepatic tissues, and the apoB, E (LDL) receptor. Three isoforms of Apo-E have been identified, ApoE2, E3 and E4, and have been linked with various disorders. ApoE2 has been shown to bind LPL receptors with low affinity, resulting in increased plasma cholesterol and triglyceride levels, and thereby an increased risk in cardiovascular disorders. ApoE4 is a known high risk factor for Alzheimer's disease, and in particular late onset Alzheimer disease 2 (AD2), whilst ApoE3 is the most common isoform, and considered the normal/natural Apo-E genotype. Clone 6-4 has been shown to inhibit Apo-E mediated binding of lipoproteins to the apoB, E cell receptor.
- Gene Name
- APOE
Antibody
- Host Species
- Mouse
- Clonality
- Monoclonal
- Clone
- WUE-4
- Isotype
- IgG1
Immunogen
- Immunogen
- Purified ApoHDL fraction.
- Immunogen Type
- Native Protein (Purified from Natural Source)
Format
- Conjugate/Label
- Biotin
- Format
- Liquid
- Formulation
- PBS, 0.09% Sodium Azide, 1% BSA
- Concentration
- 0.1 mg/mL
- Preservative
- Yes
- Purification Method
- Protein G Affinity
Storage & Handling
- Storage Conditions
- Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
- Recommended Storage Buffer
- PBS