Positive WB detected in:K562 whole cell lysate,SH-SY5Y whole cell lysate;All lanes: AIM2 antibody at 2.7ug/ml;Secondary;Goat polyclonal to rabbit IgG at 1/50000 dilution;Predicted band size: 39 kDa;Observed band size: 39,45 kDa;

AIM2 Antibody

Primary AntibodyLSBio Guarantee

Antibody:	Rabbit Polyclonal
Applications:	Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Immunohistochemistry (general), Western Blot
Reactivity:	Human
Format:	Liquid

$300.00each

Catalog Number: LS-C498354-50

Unit Size

Quantity

For bulk orders or custom formulations:

Overview

Description: AIM2 antibody LS-C498354 is an unconjugated rabbit polyclonal antibody to human AIM2. Validated for ELISA, IF, IHC and WB.
Application: ELISA, IF, IHC, WB
Reactivity: Hu
Intended Use: Research Use Only
Guarantees: This antibody carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names: Absent in melanoma 2 | AIM2 | PYHIN4
UniProt Number: O14862
NCBI GenBank: NM_004833 | NP_004824.1
SwissProt: O14862

Target

Target: Human AIM2
Antigen Species: Human
Epitope: Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.
Gene Name: AIM2