Formalin-fixed, paraffin-embedded human Spleen stained with TRAcP Rabbit Recombinant Monoclonal Antibody (ACP5/2336R).
ACP5 / TRAP Antibody (clone ACP5/2336R, Azide-free, Carrier-free)
Primary AntibodyLSBio Guarantee
| Antibody: | Rabbit Recombinant Monoclonal |
| Applications: | Immunohistochemistry, Paraffin |
| Reactivity: | Human |
| Format: | Liquid |
$586.00each
Catalog Number: LS-C751317-100
Catalog Number: LS-C751317
For bulk orders or custom formulations:
Request a QuoteOverview
- Description
- TRAP antibody LS-C751317 is an unconjugated rabbit recombinant monoclonal antibody to human TRAP (ACP5). Validated for IHC.
- Application
- IHC-P
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Recombinant Antibodies
- Alternative Names
- ACP5 | SPENCDI | TrATPase | Type 5 acid phosphatase | Tartrate-resistant acid ATPase | TR-AP | TRACP5b
- Recommended Dilution: IHC-P
- 1 - 2 µg/ml
- UniProt Number
- P13686
- NCBI GenBank
- NM_001611 | NP_001602.1
- SwissProt
- P13686
Target
- Target
- Human ACP5 / TRAP
- Antigen Species
- Human
- Epitope
- It recognizes a protein of 35 kDa , which is identified as tartrate-resistant acid phosphatase (TRAcP). It exists as two isoforms (5a and 5b). This MAb reacts with both the isoforms. Serum TRAcP 5a is secreted by macrophages and dendritic cells and increased in many patients of rheumatoid arthritis. Serum TRAcP 5b is produced from osteoclasts and elevated during bone resorption. TRAcP is an iron containing glycoprotein, which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. TRAcP is synthesized as a latent proenzyme and is activated by proteolytic cleavage and reduction. Normally, TRAcP is highly expressed by osteoclasts, activated macrophages, neurons and endometrium during pregnancy. Expression of TRAcP is increased in certain pathological conditions such as Leukemic Reticuloendotheliosis (Hairy Cell Leukemia), Gaucher s Disease, HIV-induced Encephalopathy, Osteoclastoma and in osteoporosis and metabolic bone diseases. Anti-TRAcP antibody labels the cells of Hairy Cell Leukemia (HCL) with a high degree of sensitivity and specificity. Other cells stained with this antibody are tissue macrophages and osteoclasts.
- Gene Name
- ACP5
Antibody
- Host Species
- Rabbit
- Clonality
- Recombinant Monoclonal
- Clone
- ACP5/2336R
- Isotype
- IgG
- Origin Species
- Human
Immunogen
- Immunogen
- Recombinant full-length human ACP5 protein. Antigen Molecular Weight: 35 kDa
- Immunogen Type
- Recombinant Immunogen
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- 10 mM PBS
- Concentration
- 1 mg/mL
- Preservative
- No
- Purification Method
- Protein A/G Affinity
Storage & Handling
- Storage Conditions
- Store at -20°C to -80°C for up to 2 years.
- Recommended Storage Buffer
- 10 mM PBS