Anti-ABCB4 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
ABCB4 / MDR3 Antibody (aa252-301)
| Antibody: | Rabbit Polyclonal |
| Applications: | Immunohistochemistry (general), Immunohistochemistry, Paraffin, Western Blot |
| Reactivity: | Human |
| Format: | Liquid |
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- Description
- MDR3 antibody LS-B5729 is an unconjugated rabbit polyclonal antibody to human MDR3 (ABCB4) (aa252-301). Validated for IHC and WB. Cited in 2 publications.
- Application
- IHC, IHC-P, WB
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This product carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Polyclonal Antibodies
- Alternative Names
- ABC21 | ABCB4 | ICP3 | GBD1 | MDR3 | MDR2 | Multidrug resistance protein 3 | Multiple drug resistance 3 | P-glycoprotein 3 | Pgy2 | PGY3 | PFIC-3 | MDR2/3
- Recommended Dilution: IHC-P
- 5 µg/ml
- Recommended Dilution: WB
- 0.2 - 1 µg/ml
- UniProt Number
- P21439
- NCBI GenBank
- NM_018849 | NP_061337.1
- SwissProt
- P21439
Target
- Target
- ABCB4 / MDR3
- Antigen Species
- Human
- Specificity
- Human ABCB4
- Epitope
- Human ABCB4
- Gene Name
- ABCB4
Antibody
- Host Species
- Rabbit
- Clonality
- Polyclonal
- Origin Species
- Human
Immunogen
- Immunogen
- Synthetic peptide located between aa252-301 of human ABCB4 (A4D1D4, NP_000434). Percent identity by BLAST analysis: Human, Chimpanzee, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Rabbit (100%); Galago, Panda, Opossum (92%); Bovine (85%).
- Immunogen Type
- Synthetic Peptide (Linear)
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS, 0.09% sodium azide, 2% sucrose
- Concentration
- 0.5 mg/mL
- Volume
- 50 Microliter
- Animal Free
- No
- Carrier-Free
- Yes
- Preservative
- Yes
- Purification Method
- Affinity Purified
Storage & Handling
- Storage Conditions
- Short term: Store at 2-8°C. Long term: Aliquot and store at -20°C. Avoid freeze/thaw cycles.
- Recommended Storage Buffer
- PBS
ABCB4 is frequently epigenetically silenced in human cancers and inhibits tumor growth. Kiehl S, Herkt SC, Richter AM, Fuhrmann L, El-Nikhely N, Seeger W, Savai R, Dammann RH. Scientific reports. 4:6899.
PubMed: 25367630 · PMC: PMC4219162
Gene therapy for progressive familial intrahepatic cholestasis type 3 in a clinically relevant mouse model. Weber ND, Odriozola L, Martínez-García J, Ferrer V, Douar A, Bénichou B, González-Aseguinolaza G, Smerdou C. Nature communications. 2019 December;10:5694.
PubMed: 31836711 · PMC: PMC6910969