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| Catalog Number | Size | Price |
|---|---|---|
| LS-A3434-50 | 50 µg (1 mg/ml) | $460 |
PathPlus™ Polyclonal Rabbit anti‑Human SLC7A11 / XCT Antibody (N‑Terminus, IHC) LS‑A3434
PathPlus™ Polyclonal Rabbit anti‑Human SLC7A11 / XCT Antibody (N‑Terminus, IHC) LS‑A3434
Note: This antibody replaces LS-C89190, LS-C89189, LS-C42543
Antibody:
SLC7A11 / XCT Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Overview
Antibody:
SLC7A11 / XCT Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Specifications
Description
SLC7A11 (cystine/glutamate transporter, Xc-, xCT) is a chloride-dependent cystine-glutamate antiporter involved in excitatory signaling, glutamate release and modulation of synaptic activity. In addition to glutamatergic neurotransmission, it is thought to support neuroprotective processes related to oxidative stress. Dysfunctional glutamate signaling in neurological disorders such as schizophrenia may involve impairment of SLC7A11. In immunohistochemistry, SLC7A11 has high expression in astrocytes of the basolateral amygdala and prefrontal cortex in the brain, and it is also found in the eye, with low levels of additional expression in immune, reproductive and gastrointestinal tissues.
References: Pharmacological Reviews. 64 (3): 780–802, PMID: 22759795; Journal of Psychiatric Research. 72: 58–63, PMID: 26540405; Glia. 2018 May;66(5):951-970, PMID: 29350434; NPJ Schizophr. 2017 Sep 18;3(1):31, PMID: 28924227; Antioxid Redox Signal. 2013 Feb 10; 18(5): 522–555, PMID: 22667998
Target
Human SLC7A11 / XCT
Synonyms
SLC7A11 | CCBR1 | Cystine/glutamate transporter | XCT | SLC711
Host
Rabbit
Reactivity
Human
(tested or 100% immunogen sequence identity)
Predicted
Monkey (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 19 amino acid peptide from N-Terminus of human SLC7A11. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon (100%); Monkey, Marmoset (95%); Horse (89%); Rat, Dog, Hamster (84%).
Epitope
N-Terminus
Specificity
Human SLC7A11. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
- IHC
- IHC - Paraffin (10 - 20 µg/ml)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Immunohistochemistry: The unconjugated form was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for the unconjugated form was determined to be 14-28 ug/ml.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About SLC7A11 / XCT
Validation
Anti-SLC7A11 antibody IHC of human chief cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-SLC7A11 antibody IHC of human chief cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
See More About...
LSBio Ratings
PathPlus™ SLC7A11 / XCT Antibody (N-Terminus) for IHC LS-A3434 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human, Monkey
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Species:
Human
Applications:
IHC, IHC - Paraffin
Species:
Human, Monkey
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Species:
Human
Applications:
IHC, IHC - Paraffin
Species:
Human
Applications:
Western blot, Flow Cytometry
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/18/2024
Date Requested: 4/18/2024
