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| Catalog Number | Size | Price |
|---|---|---|
| LS-A121-50 | 50 µg (1 mg/ml) | $440 |
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2 of 2
PathPlus™ Polyclonal Rabbit anti‑Human GPR3 Antibody (Extracellular Domain, IHC, IF) LS‑A121
PathPlus™ Polyclonal Rabbit anti‑Human GPR3 Antibody (Extracellular Domain, IHC, IF) LS‑A121
Antibody:
GPR3 Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Application:
IHC, IHC-P, ICC, IF
Reactivity:
Human, Monkey, Mouse, Rat, Hamster
Format:
Unconjugated, Unmodified
Overview
Antibody:
GPR3 Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Application:
IHC, IHC-P, ICC, IF
Reactivity:
Human, Monkey, Mouse, Rat, Hamster
Format:
Unconjugated, Unmodified
Specifications
Description
G protein-coupled receptor 3 (GPR3) is a constitutively active lysophospholipid/lysosphingolipid receptor. GPR3 receptor is a link in communication between the somatic cells and oocyte of the ovarian follicle where GPR3 maintains meiotic arrest in mouse oocytes. Oocytes from Gpr3 knockout mice resume meiosis within antral follicles, independently of an increase in luteinizing hormone, and mice deficient in GPR3 exhibit premature ovarian failure due to early oocyte aging (Ledent et al. 2005).
References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human GPR3
Synonyms
GPR3 | ACCA | ACCA orphan receptor | G protein-coupled receptor 3 | GPCR3 | Hacca | G-protein coupled receptor 3
Host
Rabbit
Reactivity
Human, Monkey, Mouse, Rat, Hamster
(tested or 100% immunogen sequence identity)
Predicted
Rabbit (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 15 amino acid peptide from 2nd extracellular domain of human GPR3. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster (100%); Rabbit (93%); Bovine, Panda, Pig (80%).
Epitope
Extracellular Domain
Specificity
Human GPR3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
- IHC
- IHC - Paraffin (6 µg/ml)
- ICC
- Immunofluorescence
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About GPR3
Validation
Anti-GPR3 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR3 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR3 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR3 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
See More About...
LSBio Ratings
PathPlus™ GPR3 Antibody (Extracellular Domain) for IHC, ICC, IF/Immunofluorescence LS-A121 has an LSBio Rating of
Publications (4.1)
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (2)
Premature ovarian aging in mice deficient for Gpr3. Ledent C, Demeestere I, Blum D, Petermans J, Hmlinen T, Smits G, Vassart G. Proceedings of the National Academy of Sciences of the United States of America. 2005 102:8922-6. (ICC; Mouse)
The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons. Thathiah A, Spittaels K, Hoffmann M, Staes M, Cohen A, Horr K, Vanbrabant M, Coun F, Baekelandt V, Delacourte A, Fischer DF, Pollet D, De Strooper B, Merchiers P. Science (New York, N.Y.). 2009 323:946-51. (IHC; Human)
Customer Reviews (0)
Featured Products
Species:
Human
Applications:
IHC, IHC - Paraffin, Western blot, ELISA, RNA interference
Species:
Human, Monkey, Bovine, Rabbit
Applications:
IHC, IHC - Paraffin, ELISA
Species:
Human, Monkey
Applications:
IHC, IHC - Paraffin, ELISA
Species:
Human, Monkey
Applications:
IHC, IHC - Paraffin, ELISA
Species:
Human, Monkey, Mouse, Rat, Bovine, Hamster, Pig, Rabbit
Applications:
Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Species:
Human, Monkey, Bovine, Rabbit
Applications:
IHC, IHC - Paraffin, ELISA
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/19/2024
Date Requested: 4/19/2024
