LSBio
Polyclonal Rabbit anti-Mouse TGFB1 / TGF Beta 1 Antibody (Biotin)

Polyclonal Rabbit anti-Mouse TGFB1 / TGF Beta 1 Antibody (Biotin)

Primary AntibodyLSBio Guarantee
Antibody:Rabbit Polyclonal
Applications:Enzyme-Linked Immunosorbent Assay
Reactivity:Mouse
Format:Liquid
See all Mouse TGFB1 / TGF Beta 1 antibodies →
$300.00each
Catalog Number: LS-C499927-50

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Overview

Description
TGF Beta 1 antibody LS-C499927 is a biotin-conjugated rabbit polyclonal antibody to mouse TGF Beta 1 (TGFB1). Validated for ELISA.
Application
ELISA
Reactivity
Ms
Intended Use
Research Use Only
Guarantees
This antibody carries the LSBio 100% Guarantee. ✓
Category
Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names
CED | DPD1 | Diaphyseal dysplasia 1 | LAP | Latency-associated peptide | TGF Beta | TGFbeta | TGF-beta 1 protein | TGF-beta-1 | TGFB | TGFB1
UniProt Number
P01137
NCBI GenBank
NM_000660 | NP_000651.3
SwissProt
P01137

Target

Target
Mouse TGFB1 / TGF Beta 1
Antigen Species
Mouse
Epitope
Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells (PubMed:18368049). Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus. Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types (By similarity).
Gene Name
TGFB1

Antibody

Host Species
Rabbit
Clonality
Polyclonal
Isotype
IgG

Immunogen

Immunogen
Recombinant Mouse Transforming growth factor beta-1 protein (30-391AA)
Immunogen Type
Recombinant Immunogen

Format

Conjugate/Label
Biotin
Format
Liquid
Formulation
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Preservative
Yes
Purification Method
Protein G Affinity

Storage & Handling

Storage Conditions
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
Recommended Storage Buffer
PBS

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To request an SDS/MSDS form for this product, please contact our Technical Support department at: technical@vectorlabs.com.