Formalin-fixed, paraffin-embedded human Thyroid stained with Thyroglobulin Mouse Recombinant Monoclonal Antibody (r6E1).
TG / Thyroglobulin Antibody (clone r6E1)
Primary AntibodyLSBio Guarantee
| Antibody: | Mouse Recombinant Monoclonal |
| Applications: | Immunohistochemistry (general), Immunohistochemistry, Paraffin |
| Reactivity: | Human |
| Format: | Liquid |
$379.00each
Catalog Number: LS-C751383-20
Catalog Number: LS-C751383
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- Description
- Thyroglobulin antibody LS-C751383 is an unconjugated mouse recombinant monoclonal antibody to human Thyroglobulin (TG). Validated for IHC.
- Application
- IHC, IHC-P
- Reactivity
- Hu
- Nonreactive Species
- Mouse, Rat
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Recombinant Antibodies
- Alternative Names
- AITD3 | TDH3 | Thyroglobulin | TGN | TG
- Recommended Dilution: IHC-P
- 0.25 - 0.5 µg/ml
- UniProt Number
- P01266
- NCBI GenBank
- NM_003235 | NP_003226.4
- SwissProt
- P01266
Target
- Target
- Human TG / Thyroglobulin
- Antigen Species
- Human
- Epitope
- Thyroglobulin is a 660 kDa dimeric pre-protein with mutiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.
- Gene Name
- TG
Antibody
- Host Species
- Mouse
- Clonality
- Recombinant Monoclonal
- Clone
- r6E1
- Isotype
- IgG1
- Light Chain
- Kappa Light Chain
- Origin Species
- Human
Immunogen
- Immunogen
- Human thyroid follicular cells. Antigen Molecular Weight: 660 kDa (Dimeric Form)
- Immunogen Type
- Cell-Based Immunization
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- 10 mM PBS, 0.05% BSA, 0.05% Sodium Azide
- Concentration
- 200 µg/mL
- Preservative
- Yes
- Purification Method
- Protein A/G Affinity
Storage & Handling
- Storage Conditions
- Store at 2°C to 8°C for up to 2 years.
- Recommended Storage Buffer
- 10 mM PBS