LSBio
Recombinant Monoclonal Rabbit anti-Human TFF1 / pS2 Antibody (clone TFF1/2969R, Azide-free,Carrier-free, C-Terminus, aa57-84, IHC)

Formalin-fixed, paraffin-embedded human Stomach Carcinoma stained with pS2 Rabbit Recombinant Monoclonal Antibody (TFF1/2969R).

Recombinant Monoclonal Rabbit anti-Human TFF1 / pS2 Antibody (clone TFF1/2969R, Azide-free,Carrier-free, C-Terminus, aa57-84, IHC)

Primary AntibodyLSBio Guarantee
Antibody:Rabbit Recombinant Monoclonal
Applications:Immunohistochemistry, Paraffin
Reactivity:Human
Format:Liquid
See all Human TFF1 / pS2 antibodies →
$586.00each
Catalog Number: LS-C751379-100

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Overview

Description
PS2 antibody LS-C751379 is an unconjugated rabbit recombinant monoclonal antibody to human pS2 (TFF1) (C-Terminus, aa57-84). Validated for IHC.
Application
IHC-P
Reactivity
Hu
Intended Use
Research Use Only
Guarantees
This antibody carries the LSBio 100% Guarantee. ✓
Category
Antibodies > Primary Antibodies > Recombinant Antibodies
Alternative Names
BCEI | D21S21 | HPS2 | PNR-2 | Polypeptide P1.A | Protein pS2 | PS2 | TFF1 | HP1.A | Trefoil factor 1
Recommended Dilution: IHC-P
0.5 - 1 µg/ml
UniProt Number
P04155
NCBI GenBank
NM_003225 | NP_003216.1
SwissProt
P04155

Target

Target
Human TFF1 / pS2
Antigen Species
Human
Epitope
It recognizes a polypeptide of 6.5 kDa , identified as pS2 estrogen-regulated protein. Its epitope is localized between aa57-84 of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy.
Gene Name
TFF1

Antibody

Host Species
Rabbit
Clonality
Recombinant Monoclonal
Clone
TFF1/2969R
Isotype
IgG
Origin Species
Human

Immunogen

Immunogen
Synthetic peptide of 28 amino acid residues corresponding to CFDDTVRGVPWCFYPNTIDVPPEEECEF (aa57-84) from the C-Terminus of human pS2. Antigen Molecular Weight: 6.5 kDa
Immunogen Type
Synthetic Peptide (Linear)

Format

Conjugate/Label
Unconjugated
Format
Liquid
Formulation
10 mM PBS
Concentration
1 mg/mL
Preservative
No
Purification Method
Protein A/G Affinity

Storage & Handling

Storage Conditions
Store at -20°C to -80°C for up to 2 years.
Recommended Storage Buffer
10 mM PBS

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To request an SDS/MSDS form for this product, please contact our Technical Support department at: technical@vectorlabs.com.