Formalin-fixed, paraffin-embedded Human Melanoma stained with SOX10 Rabbit Recombinant Monoclonal Antibody(SOX10/2311R).

SOX10 Antibody (aa115-269, clone SOX10/2311R)

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Antibody:	Rabbit Recombinant Monoclonal
Applications:	Immunohistochemistry (general), Immunohistochemistry, Paraffin
Reactivity:	Human
Format:	Liquid

$379.00each

Catalog Number: LS-C751362-20

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Description: SOX10 antibody LS-C751362 is an unconjugated rabbit recombinant monoclonal antibody to human SOX10 (aa115-269). Validated for IHC.
Application: IHC, IHC-P
Reactivity: Hu
Intended Use: Research Use Only
Guarantees: This antibody carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Recombinant Antibodies
Alternative Names: DOM | Transcription factor SOX-10 | WS4 | PCWH | WS2E | SOX10 | SRY-related HMG-box gene 10 | WS4C | SOX-10
Recommended Dilution: IHC-P: 1 - 2 µg/ml
UniProt Number: P56693
NCBI GenBank: NM_006941 | NP_008872.1
SwissProt: P56693

Target: Human SOX10
Antigen Species: Human
Epitope: SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas.In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells.
Gene Name: SOX10

Immunogen: Recombinant human SOX10 protein fragment (around aa115-269). Antigen Molecular Weight: 49-58 kDa
Immunogen Type: Recombinant Protein Fragment