LSBio
Monoclonal Mouse anti-Human SMAD1 Antibody (WB)

Monoclonal Mouse anti-Human SMAD1 Antibody (WB)

Primary AntibodyLSBio Guarantee
Antibody:Mouse Monoclonal
Applications:Flow Cytometry, Immunocytochemistry, Immunohistochemistry (general), Immunoprecipitation, Western Blot
Reactivity:Human, Mouse, Rat
Format:Liquid
See all Human SMAD1 antibodies →
$570.00each
Catalog Number: LS-C75853-50

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Overview

Description
SMAD1 antibody LS-C75853 is an unconjugated mouse monoclonal antibody to SMAD1 from human. It is reactive with human, mouse and rat. Validated for Flow, ICC, IP and WB. Cited in 4 publications.
Application
FC, ICC, IHC, IP, WB
Reactivity
Hu, Ms, Rt
Intended Use
Research Use Only
Guarantees
This antibody carries the LSBio 100% Guarantee.
Category
Antibodies > Primary Antibodies > Monoclonal Antibodies
Alternative Names
BSP1 | BSP-1 | JV4-1 | MADH1 | Mothers against DPP homolog 1 | JV41 | SMAD family member 1 | TGF-beta signaling protein 1 | MADR1 | SMAD1 | HSMAD1 | MAD homolog 1 | Mad-related protein 1 | SMAD 1
Recommended Dilution: FC
0.5 - 2 µg/ml
Recommended Dilution: IF/ICC
2 - 100 µg/ml
Recommended Dilution: WB
0.2 - 2 µg/ml
UniProt Number
Q15797
SwissProt
Q15797

Target

Target
Human SMAD1
Antigen Species
Human
Epitope
Recognizes human Smad1.
Gene Name
SMAD1

Antibody

Host Species
Mouse
Clonality
Monoclonal
Isotype
IgG1
Origin Species
Human

Immunogen

Immunogen
Recombinant human Smad1.
Immunogen Type
Recombinant Immunogen

Format

Conjugate/Label
Unconjugated
Format
Liquid
Formulation
PBS, pH 7.4, 0.05% Sodium Azide, 1% BSA
Concentration
0.1 mg/mL
Preservative
Yes
Purification Method
Protein G Affinity

Storage & Handling

Storage Conditions
Short term: store at 4°C. Long term: aliquot and store at -20°C. Avoid freeze-thaw cycles.
Recommended Storage Buffer
PBS

The type I BMP receptor Alk3 is required for the induction of hepatic hepcidin gene expression by interleukin-6. Mayeur C, Lohmeyer LK, Leyton P, Kao SM, Pappas AE, Kolodziej SA, Spagnolli E, Yu B, Galdos RL, Yu PB, Peterson RT, Bloch DB, Bloch KD, Steinbicker AU. Blood. Apr;123:2261-8.

PubMed: 24501215 · PMC: PMC3975261


Progesterone receptor membrane component-1 regulates hepcidin biosynthesis. Li X, Rhee DK, Malhotra R, Mayeur C, Hurst LA, Ager E, Shelton G, Kramer Y, McCulloh D, Keefe D, Bloch KD, Bloch DB, Peterson RT. The Journal of clinical investigation. 2016;126:389-401.

PubMed: 26657863 · PMC: PMC4701562


BMP type I receptor ALK2 is required for angiotensin II-induced cardiac hypertrophy. Shahid M, Spagnolli E, Ernande L, Thoonen R, Kolodziej SA, Leyton PA, Cheng J, Tainsh RE, Mayeur C, Rhee DK, Wu MX, Scherrer-Crosbie M, Buys ES, Zapol WM, Bloch KD, Bloch DB. American journal of physiology. Heart and circulatory physiology. 2016 April;310:H984-H994.

PubMed: 26873969 · PMC: PMC4867336


Transforming growth factor-ß stimulates Smad1/5 signaling in pulmonary artery smooth muscle cells and fibroblasts of the newborn mouse through ALK1. Huili Zhang, Lili Du, Ying Zhong, Kathleen C Flanders, Jesse D Roberts Jr. American journal of physiology. Lung cellular and molecular physiology. 2017 September;313:L615-L627.

PubMed: 28642261 · PMC: PMC5625261

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