Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with Retinoblastoma Recombinant Rabbit Monoclonal Antibody (RB1/2313R).
RB1 / Retinoblastoma / RB Antibody (clone RB1/2313R)
Primary AntibodyLSBio Guarantee
| Antibody: | Rabbit Recombinant Monoclonal |
| Applications: | Immunohistochemistry, Paraffin |
| Reactivity: | Human |
| Format: | Liquid |
$379.00each
Catalog Number: LS-C751336-20
Catalog Number: LS-C751336
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- Description
- RB antibody LS-C751336 is an unconjugated rabbit recombinant monoclonal antibody to human RB (RB1 / Retinoblastoma). Validated for IHC.
- Application
- IHC-P
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Recombinant Antibodies
- Alternative Names
- p105-Rb | Osteosarcoma | PRb | RB1 | Retinoblastoma | Retinoblastoma 1 | OSRC | RB | Pp110
- Recommended Dilution: IHC-P
- 1 - 2 µg/ml
- UniProt Number
- P06400
- NCBI GenBank
- NM_000321 | NP_000312.2
- SwissProt
- P06400
Target
- Target
- Human RB1 / Retinoblastoma / RB
- Antigen Species
- Human
- Epitope
- Recognizes a 105 kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. Its epitope is localized between aa 703-772. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.
- Gene Name
- RB1
Antibody
- Host Species
- Rabbit
- Clonality
- Recombinant Monoclonal
- Clone
- RB1/2313R
- Isotype
- IgG
- Origin Species
- Human
Immunogen
- Immunogen
- Recombinant full-length human Rb1 protein. Antigen Molecular Weight: 105 kDa
- Immunogen Type
- Recombinant Immunogen
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- 10 mM PBS, 0.05% BSA, 0.05% Sodium Azide
- Concentration
- 200 µg/mL
- Preservative
- Yes
- Purification Method
- Protein A/G Affinity
Storage & Handling
- Storage Conditions
- Store at 2°C to 8°C for up to 2 years.
- Recommended Storage Buffer
- 10 mM PBS