Formalin-fixed, paraffin-embedded human placenta stained with PLAP Mouse Monoclonal Antibody (ALPP/2889R).
PLAP / Alkaline Phosphatase Antibody (clone ALPP/2889R, Azide-free, Carrier-free)
Primary AntibodyLSBio Guarantee
| Antibody: | Rabbit Recombinant Monoclonal |
| Applications: | Immunohistochemistry, Paraffin |
| Reactivity: | Human |
| Format: | Liquid |
$586.00each
Catalog Number: LS-C751147-100
Catalog Number: LS-C751147
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- Description
- Alkaline Phosphatase antibody LS-C751147 is an unconjugated rabbit recombinant monoclonal antibody to human Alkaline Phosphatase (PLAP). Validated for IHC.
- Application
- IHC-P
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Recombinant Antibodies
- Alternative Names
- ALP | Alkaline phosphomonoesterase | ALPP | Glycerophosphatase | PALP | PLAP | PLAP-1 | Alp1 | Germ-cell alkaline phosphatase | Nagao isozyme | Regan isozyme
- Recommended Dilution: IHC-P
- 0.25 - 0.5 µg/ml
- UniProt Number
- P05187
- NCBI GenBank
- NM_001632 | NP_001623.3
- SwissProt
- P05187
Target
- Target
- Human PLAP / Alkaline Phosphatase
- Antigen Species
- Human
- Epitope
- Reacts with a 70 kDa membrane-bound isozyme (Regan and Nagao type) of Placental Alkaline Phosphatase (PLAP) occurring in the placenta during the 3rd trimester of gestation. It is highly specific for PLAP and shows no cross-reaction with other isozymes of alkaline phosphatase. Anti-PLAP reacts with germ cell tumors and can discriminate between these and other neoplasms. Somatic neoplasms e.g. breast, gastrointestinal, prostatic, and urinary cancers may also immunoreact with antibodies to PLAP. Anti-PLAP positivity in conjunction with anti-keratin negativity favors seminoma over carcinoma. Germ cell tumors are usually anti-keratin positive, but they regularly fail to stain with anti-EMA, whereas most carcinomas stain with anti-EMA. Anti-PLAP has been useful in the diagnosis of gestational trophoblastic disease.
- Gene Name
- ALPP
Antibody
- Host Species
- Rabbit
- Clonality
- Recombinant Monoclonal
- Clone
- ALPP/2889R
- Isotype
- IgG
- Origin Species
- Human
Immunogen
- Immunogen
- Recombinant full-length human ALPP protein. Antigen Molecular Weight: 70 kDa
- Immunogen Type
- Recombinant Immunogen
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- 10 mM PBS
- Concentration
- 1 mg/mL
- Preservative
- No
- Purification Method
- Protein A/G Affinity
Storage & Handling
- Storage Conditions
- Store at -20°C to -80°C for up to 2 years.
- Recommended Storage Buffer
- 10 mM PBS