NK1.1 / NK Cells Antibody (clone PK136)
Primary AntibodyLSBio Guarantee
| Antibody: | Mouse Monoclonal |
| Applications: | Cytotoxicity Assay, Flow Cytometry, Immunoprecipitation |
| Reactivity: | Mouse |
| Format: | Liquid |
$392.00each
Catalog Number: LS-C43392-0.25
Catalog Number: LS-C43392
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- Description
- NK Cells antibody LS-C43392 is an unconjugated mouse monoclonal antibody to mouse NK Cells (NK1.1). Validated for Ctox, Flow and IP.
- Application
- CTA, FC, IP
- Reactivity
- Ms
- Nonreactive Species
- Hu, Rt
- Intended Use
- RUO
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Monoclonal Antibodies
Target
- Target
- Mouse NK1.1 / NK Cells
- Antigen Species
- Ms
- Epitope
- Recognizes the mouse NK1.1 cell surface antigen, a cell surface glycoprotein encoded by members of the NKR-P1 gene family. The NK1.1 surface antigen is also known as CD161b/CD161c and Ly-55. In the mouse the NKR-P1 family has three members, NKR-P1A, -B and -C, whilst in the human only one member has been identified. The human protein has received the designation CD161, and the mouse proteins have been referred to as CD161a, -b, -c etc. Although previously thought to recognize only CD161c, recent data has shown that the PK136 antibody may also react with CD161b. CD161c expression itself is strain specific in mice, but recognition of CD161b by PK136 appears to be even more complex, as only some CD161b positive strains are labeled by the antibody. Engagement of CD161c has been reported to have activating function in NK cells, whilst engagement of CD161b is inhibitory. Is useful for the identification of NK cells in selected strains of mice (positive on C57BL, FVB/N and NZB, but negative on AKR and BALB/c) and is also expressed by rare subsets of T cells and monocytes. Has also been used for in vivo depletion of NK cells and in vitro activation of NK cells.
Antibody
- Host Species
- Ms
- Clonality
- Monoclonal
- Clone
- PK136
- Isotype
- IgG2a
Immunogen
- Immunogen
- Spleen and bone marrow cells from CE mice.
- Immunogen Type
- Cell
Format
- Conjugate/Label
- Unconj
- Format
- Liquid
- Formulation
- PBS, 0.09% Sodium Azide
- Concentration
- 1 mg/mL
- Preservative
- Yes
- Purification Method
- Prot A
Storage & Handling
- Storage Conditions
- Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
- Recommended Storage Buffer
- PBS