Lamin A antibody Western blot. All lanes: Anti Lamin A at 0.5 ug/ml. Lane 1: Human Placenta Tissue Lysate at 50 ug. Lane 2: SKOV Whole Cell Lysate at 40 ug. Lane 3: SW620 Whole Cell Lysate at 40 ug. Lane 4: COLO320 Whole Cell Lysate at 40 ug. Lane 5: HELA Whole Cell Lysate at 40 ug. Lane 6: 293T Whole Cell Lysate at 40 ug. Lane 7: A549 Whole Cell Lysate at 40 ug. Predicted band size: 74 kD. Observed band size: 74 kD.
LMNA / Lamin A+C Antibody (aa481-646)
Primary AntibodyLSBio Guarantee
| Antibody: | Rabbit Polyclonal |
| Applications: | Immunocytochemistry, Immunohistochemistry (general), Immunohistochemistry, Paraffin, Western Blot |
| Reactivity: | Human, Mouse, Rat |
| Format: | Lyophilized |
$480.00each
Catalog Number: LS-C357473-100
Catalog Number: LS-C357473
For bulk orders or custom formulations:
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- Description
- Lamin A+C antibody LS-C357473 is an unconjugated rabbit polyclonal antibody to Lamin A+C (LMNA) (aa481-646) from human. It is reactive with human, mouse and rat. Validated for ICC, IHC and WB.
- Application
- ICC, IHC, IHC-P, WB
- Reactivity
- Hu, Ms, Rt
- Intended Use
- RUO
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Polyclonal Antibodies
- Alternative Names
- 70 kDa lamin | CDCD1 | CMD1A | EMD2 | FPLD | IDC | FPL | FPLD2 | Lamin A/C | Lamin | LFP | LMNA | LMNC | LMN1 | LMNL1 | HGPS | Prelamin-A/C | PRO1 | Lamin A | Lamin A/C-like 1 | LGMD1B | CDDC | CMT2B1 | LDP1
- UniProt Number
- P02545
- NCBI GenBank
- NM_005572, NP_005563.1
- SwissProt
- P02545
Target
- Target
- Human LMNA / Lamin A+C
- Antigen Species
- Hu
- Epitope
- In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is prevalent in medial vascular smooth muscle cells (VSMCs) from aged individuals and in atherosclerotic lesions, where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of ZMPSTE24/FACE1 in response to oxidative stress. .
- Gene Name
- LMNA
Antibody
- Host Species
- Rb
- Clonality
- Polyclonal
Immunogen
- Immunogen
- E.coli-derived human Lamin A/C recombinant protein (Position: Y481-Y646). Human Lamin A/C shares 90% and 92% amino acid (aa) sequence identity with mouse and rat Lamin A/C, respectively.
- Immunogen Type
- Recom
Format
- Conjugate/Label
- Unconj
- Format
- Lyophilized
- Formulation
- Lyophilized from 0.2mg Na2HPO4, 5mg BSA, 0.9mg NaCl, 0.05mg sodium azide.
- Concentration
- 0.5 mg/mL
- Preservative
- Yes
- Purification Method
- AP
Storage & Handling
- Storage Conditions
- At -20°C for 1 year. After reconstitution, at 4°C for 1 month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid freeze-thaw cycles.
- Recommended Storage Buffer
- NaCl