Formalin-paraffin human Small Intestine stained with Cytokeratin 8 Rabbit Recombinant Monoclonal Antibody (KRT8/2174R).
KRT8 / CK8 / Cytokeratin 8 Antibody (clone KRT8/2174R)
Primary AntibodyLSBio Guarantee
| Antibody: | Rabbit Recombinant Monoclonal |
| Applications: | Immunohistochemistry (general), Immunohistochemistry, Paraffin |
| Reactivity: | Human |
| Format: | Liquid |
$379.00each
Catalog Number: LS-C751222-20
Catalog Number: LS-C751222
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- Description
- Cytokeratin 8 antibody LS-C751222 is an unconjugated rabbit recombinant monoclonal antibody to human Cytokeratin 8 (KRT8 / CK8). Validated for IHC.
- Application
- IHC, IHC-P
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Recombinant Antibodies
- Alternative Names
- CARD2 | CK-8 | CYK8 | Cytokeratin-8 | CK8 | K2C8 | K8 | KO | Keratin-8 | KRT8 | Type-II keratin Kb8 | Cytokeratin 8 | Keratin 8
- Recommended Dilution: IHC-P
- 0.5 - 1 µg/ml
- UniProt Number
- P05787
- NCBI GenBank
- NM_002273 | NP_002264.1
- SwissProt
- P05787
Target
- Target
- Human KRT8 / CK8 / Cytokeratin 8
- Antigen Species
- Human
- Epitope
- Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular weight cytokeratins and exists in combination with cytokeratin 18 (CK18). CK8 is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Hepatocellular carcinomas are defined by the use of antibodies that recognize only cytokeratin 8 and 18. CK8 exists on several types of normal and neoplastic epithelia, including many ductal and glandular epithelia such as colon, stomach, small intestine, trachea, and esophagus as well as in transitional epithelium. Anti-CK8 does not react with skeletal muscle or nerve cells. Epithelioid sarcoma, chordoma, and adamantinoma show strong positivity corresponding to that of simple epithelia (with antibodies against CK8, CK18 and CK19). Reportedly, anti-CK8 is useful for the differentiation of lobular ( ring-like, perinuclear ) from ductal ( peripheral-predominant ) carcinoma of the breast.
- Gene Name
- KRT8
Antibody
- Host Species
- Rabbit
- Clonality
- Recombinant Monoclonal
- Clone
- KRT8/2174R
- Isotype
- IgG
- Origin Species
- Human
Immunogen
- Immunogen
- Recombinant full-length human KRT8 protein. Antigen Molecular Weight: 52.5 kDa
- Immunogen Type
- Recombinant Immunogen
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- 10 mM PBS, 0.05% BSA, 0.05% Sodium Azide
- Concentration
- 200 µg/mL
- Preservative
- Yes
- Purification Method
- Protein A/G Affinity
Storage & Handling
- Storage Conditions
- Store at 2°C to 8°C for up to 2 years.
- Recommended Storage Buffer
- 10 mM PBS