LSBio
Polyclonal Rabbit anti-Human HSPA8 / HSC70 Antibody (IHC, WB)

Positive WB detected in:HEK293 whole cell lysate,A549 whole cell lysate,Colo320 whole cell lysate,Hela whole cell lysate,HepG2 whole cell lysate,Mouse brain tissue,Rat brain tissue,Rat lung tissue;All lanes:HSPA8 antibody at 3.5?g/ml;Secondary;Goat polyclonal to rabbit IgG at 1/50000 dilution;Predicted band size: 71,54 KDa;Observed band size: 71 KDa;

Polyclonal Rabbit anti-Human HSPA8 / HSC70 Antibody (IHC, WB)

Primary AntibodyLSBio Guarantee
Antibody:Rabbit Polyclonal
Applications:Enzyme-Linked Immunosorbent Assay, Immunohistochemistry (general), Western Blot
Reactivity:Human, Mouse, Rat
Format:Liquid
See all Human HSPA8 / HSC70 antibodies →
$300.00each
Catalog Number: LS-C500056-50

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Overview

Description
HSC70 antibody LS-C500056 is an unconjugated rabbit polyclonal antibody to HSC70 (HSPA8) from human. It is reactive with human, mouse and rat. Validated for ELISA, IHC and WB.
Application
ELISA, IHC, WB
Reactivity
Hu, Ms, Rt
Intended Use
RUO
Guarantees
This antibody carries the LSBio 100% Guarantee. ✓
Category
Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names
Heat shock 70 kDa protein 8 | Heat shock 70kd protein 10 | Heat shock 70kD protein 8 | Heat shock cognate protein 54 | HSP71 | HSPA10 | HSC71 | HSP73 | HSPA8 | LPS-associated protein 1 | Heat shock 70kDa protein 8 | NIP71 | HSC54 | HSC70 | LAP1
UniProt Number
P11142
NCBI GenBank
NM_006597, NP_006588.1
SwissProt
P11142

Target

Target
Human HSPA8 / HSC70
Antigen Species
Hu
Epitope
Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase CHIP.
Gene Name
HSPA8

Antibody

Host Species
Rb
Clonality
Polyclonal
Isotype
IgG

Immunogen

Immunogen
Recombinant Human Heat shock cognate 71 kDa protein protein (418-597AA)
Immunogen Type
Recom

Format

Conjugate/Label
Unconj
Format
Liquid
Formulation
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Preservative
Yes
Purification Method
Prot G

Storage & Handling

Storage Conditions
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
Recommended Storage Buffer
PBS

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