Formalin-fixed, paraffin-embedded human Skin stained with Filaggrin Rabbit Recombinant Monoclonal Antibody (FLG/1957R).
FLG / Filaggrin Antibody (aa 198-288, clone FLG/1957R)
Primary AntibodyLSBio Guarantee
| Antibody: | Rabbit Recombinant Monoclonal |
| Applications: | Immunohistochemistry, Paraffin |
| Reactivity: | Human |
| Format: | Liquid |
$379.00each
Catalog Number: LS-C751132-20
Catalog Number: LS-C751132
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- Description
- Filaggrin antibody LS-C751132 is an unconjugated rabbit recombinant monoclonal antibody to human Filaggrin (FLG) (aa 198-288). Validated for IHC.
- Application
- IHC-P
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Recombinant Antibodies
- Alternative Names
- ATOD2 | FLG | Epidermal filaggrin | Filaggrin
- Recommended Dilution: IHC-P
- 0.5 - 1 µg/ml
- UniProt Number
- P20930
- NCBI GenBank
- NM_002016 | NP_002007.1
- SwissProt
- P20930
Target
- Target
- Human FLG / Filaggrin
- Antigen Species
- Human
- Epitope
- Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.
- Gene Name
- FLG
Antibody
- Host Species
- Rabbit
- Clonality
- Recombinant Monoclonal
- Clone
- FLG/1957R
- Isotype
- IgG
- Origin Species
- Human
Immunogen
- Immunogen
- Recombinant human Filaggrin protein fragment (around aa 198-288). Antigen Molecular Weight: 26-45 kDa (Processed) - 350 kDa (Profilaggrin)
- Immunogen Type
- Recombinant Protein Fragment
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- 10 mM PBS, 0.05% BSA, 0.05% Sodium Azide
- Concentration
- 200 µg/mL
- Preservative
- Yes
- Purification Method
- Protein A/G Affinity
Storage & Handling
- Storage Conditions
- Store at 2°C to 8°C.
- Recommended Storage Buffer
- 10 mM PBS