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Polyclonal Rabbit anti-Human ERN1 / IRE1 Antibody (IHC)

Immunohistochemistry of paraffin-embedded human lymph node tissue using ERN1 Antibody at dilution of 1:100

Polyclonal Rabbit anti-Human ERN1 / IRE1 Antibody (IHC)

Primary AntibodyLSBio Guarantee
Antibody:Rabbit Polyclonal
Applications:Enzyme-Linked Immunosorbent Assay, Immunohistochemistry (general)
Reactivity:Human
Format:Liquid
See all Human ERN1 / IRE1 antibodies →
$300.00each
Catalog Number: LS-C498823-50

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Overview

Description
IRE1 antibody LS-C498823 is an unconjugated rabbit polyclonal antibody to human IRE1 (ERN1). Validated for ELISA and IHC.
Application
ELISA, IHC
Reactivity
Hu
Intended Use
RUO
Guarantees
This antibody carries the LSBio 100% Guarantee. ✓
Category
Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names
ERN1 | ER to nucleus signalling 1 | Inositol-requiring enzyme 1 | Inositol-requiring protein 1 | Ire1-alpha | IRE1a | HIRE1p | IRE1 | Inositol-requiring 1 | IRE1P
UniProt Number
O75460
NCBI GenBank
NM_001433, NP_001424.3
SwissProt
O75460

Target

Target
Human ERN1 / IRE1
Antigen Species
Hu
Epitope
Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.
Gene Name
ERN1

Antibody

Host Species
Rb
Clonality
Polyclonal
Isotype
IgG

Immunogen

Immunogen
Recombinant Human Serine/threonine-protein kinase/endoribonuclease IRE1 protein (493-561AA)
Immunogen Type
Recom

Format

Conjugate/Label
Unconj
Format
Liquid
Formulation
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Preservative
Yes
Purification Method
Prot G

Storage & Handling

Storage Conditions
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
Recommended Storage Buffer
PBS

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