Formalin-fixed, paraffin-embedded human Skeletal Muscle stained with Desmin Rabbit Recombinant Monoclonal Antibody (DES/2960R).
DES / Desmin Antibody (clone DES/2960R, Azide-free, Carrier-free)
Primary AntibodyLSBio Guarantee
| Antibody: | Rabbit Recombinant Monoclonal |
| Applications: | Immunohistochemistry, Paraffin |
| Reactivity: | Human |
| Format: | Liquid |
$586.00each
Catalog Number: LS-C751116-100
Catalog Number: LS-C751116
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- Description
- Desmin antibody LS-C751116 is an unconjugated rabbit recombinant monoclonal antibody to human Desmin (DES). Validated for IHC.
- Application
- IHC-P
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Recombinant Antibodies
- Alternative Names
- ARVC7 | ARVD7 | CMD1I | CSM1 | CSM2 | DES | MFM1 | SCPNK | Desmin | Intermediate filament protein
- Recommended Dilution: IHC-P
- 1 - 2 µg/ml
- UniProt Number
- P17661
- NCBI GenBank
- NM_001927 | NP_001918.3
- SwissProt
- P17661
Target
- Target
- Human DES / Desmin
- Antigen Species
- Human
- Epitope
- Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain alpha-helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles. Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.
- Gene Name
- DES
Antibody
- Host Species
- Rabbit
- Clonality
- Recombinant Monoclonal
- Clone
- DES/2960R
- Isotype
- IgG
- Origin Species
- Human
Immunogen
- Immunogen
- Recombinant full-length human DES protein. Antigen Molecular Weight: 52 kDa
- Immunogen Type
- Recombinant Immunogen
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- 10 mM PBS
- Concentration
- 1 mg/mL
- Preservative
- No
- Purification Method
- Protein A/G Affinity
Storage & Handling
- Storage Conditions
- Store at -20°C to -80°C for up to 2 years.
- Recommended Storage Buffer
- 10 mM PBS