Human CDX2

Rabbit

Human (tested or 100% immunogen sequence identity)

IgG Recombinant Monoclonal

CDX2/2951R

Unconjugated

Protein A/G purified

Azide-free, Carrier-free. Also available Unmodified.

Recombinant fragment (around aa150-249) of human CDX2 protein. Antigen Molecular Weight: 40 kDa

aa150-249

The intestine-specific transcription factors CDX1 and CDX2 are important for directing intestinal development, differentiation, proliferation and maintenance of the intestinal phenotype. CDX2 protein expression has been seen in GI carcinomas. Anti-CDX2 has been useful to establish GI origin of metastatic adenocarcinomas and carcinoids and is especially useful to distinguish metastatic colorectal adenocarcinoma from lung adenocarcinoma. However, mucinous carcinomas of the ovary also express CDX2 protein. It limits the usefulness of this marker in the distinction of metastatic colorectal adenocarcinoma from mucinous carcinoma of the ovary.

• IHC - Paraffin (1 - 2 µg/ml)
• ELISA (2 - 4 µg/ml)

ELISA (Use Ab at 2-4 ug/ml for coating) - Immunohistology (Formalin-fixed - 1-2 ug/ml for 30 min at RT - Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes.) Optimal dilution for a specific application should be determined.

10 mM PBS

Store at -20°C to -80°C for up to 2 years.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: Q99626 NCBI: NM_001265 NP_001256.3