Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
IHC - Paraffin (1:1000)
Specificity and Use
DEF / Defensin antibody was raised against native defensins
Several defensins are recognized, the epitope has not been further characterized. Biological functions: Various functions have been described for defensins. They are antibacterial, antifungal, chemotactic for monocytes, inhibitory for ACTH-induced corticosteroid synthesis and cytotoxic for cells. Defensins are inhibited by glucosaminoglycans (self protection for cells) and high concentrations of Calpha 2+ ions. Biochemistry: Defensins are a group of cyclic peptides containing 29-35 amino acids (MW < 3500) which tend to form aggregates. The molecules are protease resistant. The defensin content of azurophilic granules in neutrophils is approximately 30% of the total protein. Specificity: Human: Defensin 1-3 (HNP-1 to HNP-3) in human neutrophils. Synthetic defensin-1 and -2 (Bachem, Bubendorf CH) stain also positively. Not tested with Defensin-4. A side reaction to elastin has been observed in humans. Other: not tested. Defensins have been described in rabbits (NP-1 to NP-5, NP3a = Corticostatin), and in mice (cryptodin).
Lyophilized from PBS pH 7.2, 5mg/ml BSA, 0.09% sodium azide