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Anti-Cytochrome B245 Heavy Chain Antibody (clone CS9) LS-C188534


Wt. Vol. Conc. Price
100 µg - 1 mg/ml Unavailable

Most Popular Cytochrome B245 Heavy Chain Antibodies

Anti-Cytochrome B245 Heavy Chain Antibody (clone NL7) LS-C188532
Mouse Monoclonal [clone NL7] (IgG1) to Human Cytochrome B245 Heavy Chain
IHC - Frozen, Western blot, Flow Cytometry, ELISA
Flow Cytometry Image
Anti-Cytochrome B245 Heavy Chain Antibody (clone CS9) LS-C188534
Mouse Monoclonal [clone CS9] (IgG1) to Human Cytochrome B245 Heavy Chain
IHC - Frozen, Western blot, Immunoprecipitation, Flow Cytometry, ELISA

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone CS9] (IgG1) to Human Cytochrome B245 Heavy Chain
IHC - Frozen, Western blot, Immunoprecipitation, Flow Cytometry, ELISA


Human Cytochrome B245 Heavy Chain
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [CS9]
Protein G purified


  • IHC - Frozen
  • Western blot
  • Immunoprecipitation
  • Flow Cytometry (1:10 - 1:100)

Specificity and Use

Cytochrome B245 solubilized in octyl-beta-gluycopyranoside.
Recognizes the light chain of cytochrome B245, also known as p22phox, a subunit of the nicotinamide adenine dinucleotide phosphate-oxidase (NADPH oxidase). NADPH oxidase is a membrane-bound enzyme complex in neutrophils that produces the superoxide anion (O2-) by transferring single electrons from NADPH inside the cell across the membrane and coupling them to molecular oxygen. Superoxide is used for the destruction of pathogens. Individuals with defects in NADPH oxidase suffer from chronic granulomatous disease, characterized by severe recurrent infections. The light chain (p22phox), along with the heavy chain (gp91phox) form cytochrome B245 (also known as flavocytochome b, or Cyt b), which is always membrane-resident. Upon the appropriate stimulus, other components of NADPH oxidase (p47phox, p40phox, p67phox and Rac2) rapidly translocate from the cytosol to the cell membrane to form the complete enzyme complex. Cytochrome B245 appears to serve as a scaffold for the assembly of the other cytosolic units of the oxidase and to provide a transmembrane pathway for electrons. The core region of the CS9 epitope is amino acids 165 - 169 (KKPSE), a cytosolic epitope on p22phox not accessible on intact neutrophils. Clone CS9 also has an inhibitory effect on NADPH oxidase activation.


PBS, 0.09% sodium azide
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

About Cytochrome B245 Heavy Chain

Requested From: 
Date Requested: 4/24/2017

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