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Anti-CUL7 Antibody (C-Terminus) IHC-plus™ LS-B362

Note: This antibody replaces LS-C18820

Ordering

Wt. Vol. Conc. Price
- 50 µl 85 mg/ml $395
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Related Products

Most Popular CUL7 Antibodies

Anti-CUL7 Antibody (C-Terminus) IHC-plus™ LS-B362
Rabbit Polyclonal to Human CUL7
Human
IHC - Paraffin, Western blot, Immunoprecipitation, ELISA
Unconjugated
Immunohistochemistry Image
Anti-CUL7 Antibody (aa1763-1782) LS-C128434
Rabbit Polyclonal to Human CUL7
Human, Monkey, Bat
Western blot, ELISA
Unconjugated

100% Guaranteed 100% Guaranteed Publications Publications (2)
Rabbit Polyclonal to Human CUL7
Human
IHC - Paraffin, Western blot, Immunoprecipitation, ELISA
Unconjugated

Details

Human CUL7
Rabbit
Human (tested or 100% immunogen sequence identity)
Polyclonal
Unconjugated
Delipidated and defibrinated
Unmodified

Applications

  • IHC - Paraffin (1:500)
  • Western blot (1:500 - 1:1000)
  • Immunoprecipitation
  • ELISA (1:2000 - 1:10000)

Specificity and Use

CUL7 antibody was raised against synthetic peptide from human CUL7 / Cullin 7.
C-Terminus
Amino acids 1679-1698 of Human Cul7 (C-terminus) coupled to KLH.
Immunohistochemistry: LS-B362 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B362 was determined to be 1:500.

Packaging

Serum, 0.01% sodium azide.
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

Publications (2)

1
CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex. Dias DC, Dolios G, Wang R, Pan ZQ. Proceedings of the National Academy of Sciences of the United States of America. 2002 99:16601-6. [PubMed:12481031] [PMC:PMC139190]
2
Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis. Arai T, Kasper JS, Skaar JR, Ali SH, Takahashi C, DeCaprio JA. Proceedings of the National Academy of Sciences of the United States of America. 2003 100:9855-60. [PubMed:12904573] [PMC:PMC187864]

About CUL7

Q14999 NM_014780 NP_055595.2

CUL7 Antibody, Cullin 7 Antibody, Cullin-7 Antibody, CUL-7 Antibody, DJ20C7.5 Antibody, KIAA0076 Antibody

Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695). Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5 (PubMed:24793696).

Immunohistochemistry

Immunohistochemistry
Anti-CUL7 / Cullin 7 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B362 dilution 1:500.
 

Requested From: United States
Date Requested: 12/8/2016

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