Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
COLEC11 Antibody, 3MC2 Antibody, CL-K1-I Antibody, CL-K1-II Antibody, CL-K1-IIb Antibody, Collectin sub-family member 11 Antibody, Collectin kidney I Antibody, Collectin kidney protein 1 Antibody, CL-K1 Antibody, CL-K1-IIa Antibody, Collectin-11 Antibody
COLEC11 is a member of the collectin family of C-type lectins that possess collagen-like sequences and carbohydrate recognition domains. Collectins are secreted proteins that play important roles in the innate immune system by binding to carbohydrate antigens on microorganisms, facilitating their recognition and removal. The encoded protein binds to multiple sugars with a preference for fucose and mannose. Mutations in this gene are a cause of 3MC syndrome-2.
Formalin-fixed and paraffin-embedded human hepatocarcinoma with COLEC11 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Western blot of COLEC11 (arrow) using rabbit polyclonal COLEC11 Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the COLEC11 gene.
Western blot of COLEC11 Antibody in MDA-MB231 cell line lysates (35 ug/lane). COLEC11 (arrow) was detected using the purified antibody.
Flow cytometric of MDA-231 cells using COLEC11 Antibody (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.