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Anti-CLCN1 / CLC-1 Antibody (C-Terminus) LS-C6116

Ordering

Wt. Vol. Conc. Price
- 50 µl - $405
Inquire for larger quantities

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Rabbit Polyclonal (IgG) to Rat CLCN1 / CLC-1
Rat
Western blot, ELISA
Unconjugated

Details

Rat CLCN1 / CLC-1
Rabbit
Rat (tested or 100% immunogen sequence identity)
Human, Mouse, Dog (at least 90% immunogen sequence identity)
IgG Polyclonal
Antiserum

Applications

Western blot (1:1000 - 1:5000), ELISA (1:10000 - 1:50000)

Specificity and Use

CLCN1 / CLC-1 antibody was raised against an 18 AA Peptide sequence near the C-terminus of rat CLC-1 (1). The peptide was coupled to KLH.
C-Terminus
The 18 AA rat control peptide 100% conserved in mouse, rat and human CLC-1. No significant sequence homology is detected with other CLCs or other proteins. Because of the low MW (<3kD) of the control peptide, it is not recommended for Western. The control peptide is available to confirm specificity of antibodies.
Suitable for use in ELISA, Western Blot. Western Blot: 1:1000-1:5000 for neat serum and 1-10 ug/ml for affinity pure antibody using ECL. ELISA:1:10000-1:50000 for neat serum and 0.5-1 ug/ml for affinity purified. Control peptide can be used to coat ELISA plates at 1 ug/ml.

Packaging

PBS, 0.05% sodium azide.
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
For research use only.

About CLCN1 / CLC-1

P35523 NM_000083 NP_000074.2

CLCN1 Antibody, Chloride channel protein 1 Antibody, ClC-1 Antibody, SMCC1 Antibody, Chloride channel 1 Antibody, CLC1 Antibody

The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. The protein encoded by this gene regulates the electric excitability of the skeletal muscle membrane. Mutations in this gene cause two forms of inherited human muscle disorders: recessive generalized myotonia congenita (Becker) and dominant myotonia (Thomsen).

Requested From: United States
Date Requested: 9/27/2016

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