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Anti-BACE1 / BACE Antibody (C-Terminus) LS-C377

Note: This antibody replaces LS-C59550, LS-C11526

Ordering

Wt. Vol. Conc. Price
100 µg - 0.5 mg/ml Unavailable

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100% Guaranteed 100% Guaranteed
Rabbit Polyclonal to Human BACE1 / BACE
Human, Mouse
ICC, Western blot
Unconjugated

Details

Human BACE1 / BACE
Rabbit
Human, Mouse (tested or 100% immunogen sequence identity)
Polyclonal
Unconjugated
Ion exchange chromatography
Unmodified

Applications

  • ICC
  • Western blot (0.5 - 1 µg/ml)

Specificity and Use

BACE1 / BACE antibody was raised against synthetic peptide from human BACE1.
LS-E29928 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-C377. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
C-Terminus
peptide corresponding to 17 amino acids at the carboxy terminus of human BACE

Packaging

PBS, 0.02% sodium azide.
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
For research use only.

About BACE1 / BACE

P56817 NM_012104 NP_036236.1

BACE1 Antibody, APP beta-secretase Antibody, Asp 2 Antibody, ASP2 Antibody, Aspartyl protease 2 Antibody, Aspartylprotease 2 Antibody, Beta-secretase Antibody, Beta-site APP-cleaving enzyme Antibody, BACE Antibody, HSPC104 Antibody, KIAA1149 Antibody, B-Secretase Antibody, Beta-secretase 1 Antibody, Memapsin-2 Antibody

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.

Immunocytochemistry

Immunocytochemistry
Immunocytochemistry of BACE in 3T3 cells with BACE antibody at 10 µg/ml.

Western blot

Western blot
Western blot of BACE in human brain tissue lysate in the absence (A) or presence (B) of blocking peptide (2253P) and in mouse 3T3 cell lysate (C) with BACE antibody at 1 ug/ml.

Requested From: 
Date Requested: 4/23/2017

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