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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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ANAPC11 / APC11 Antibody (C‑Terminus) LS‑C19022 Best Seller
Antibody
APC11 antibody LS-C19022 is an unconjugated rabbit polyclonal antibody to human APC11 (ANAPC11). Validated for ELISA, IP and WB. Cited in 2 publications.
Catalog
Size
Price
LS-C19022-100
100 µl
Unavailable

Popular ANAPC11 / APC11 Products

Anti-ANAPC11 / APC11 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6980 concentration 5 ug/ml.
Species: Human, Mouse, Rat
Applications: IHC, IHC - Paraffin, Western blot, ELISA
IHC of paraffin-embedded Human pancreas tissue using anti-ANAPC11 mouse monoclonal antibody.
Species: Human
Applications: IHC, IHC - Paraffin, Immunofluorescence, Western blot
IHC of paraffin-embedded Human Kidney tissue using anti-ANAPC11 mouse monoclonal antibody.
Species: Human
Applications: IHC, IHC - Paraffin, Immunofluorescence, Western blot
IHC of paraffin-embedded Human Kidney tissue using anti-ANAPC11 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
Species: Human
Applications: IHC, IHC - Paraffin, Immunofluorescence, Western blot

Product Description

APC11 antibody LS-C19022 is an unconjugated rabbit polyclonal antibody to human APC11 (ANAPC11). Validated for ELISA, IP and WB. Cited in 2 publications.
About ANAPC11 / APC11
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Q9NYG5 NM_016476 NP_057560.8

ANAPC11 Antibody, Apc11p Antibody, APC11 Antibody, Cyclosome subunit 11 Antibody, HSPC214 Antibody


Specifications

Target
Human ANAPC11 / APC11
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Delipidated and defibrinated
Modifications
Unmodified
Applications
  • Western blot (1:500 - 1:1000)
  • Immunoprecipitation
  • ELISA (1:2000 - 1:10000)
Immunogen
ANAPC11 / APC11 antibody was raised against synthetic peptide from human ANAPC11 / APC11.
Epitope
C-Terminus
Specificity
Amino acids 76-84 of Human APC11 (C-terminal) coupled to KLH.
Usage
This antibody reacts with human APC11 by western blot and immunoprecipitation. The antibody immunoprecipitates in vitro translated protein and protein from overexpressing cell lysates (using HeLa and NIH-3T3, and others). Coimmunoprecipitation of related proteins (APC2) does occur. A 9.8 kD band corresponding to human APC11 is detected. Most cell lines or tissues expressing APC11 can be used as a positive control. Researchers should determine optimal titers for other applications.
Presentation
0.01% sodium azide.
Storage
Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid freeze-thaw cycles. Centrifuge product if not completely clear after standing at room temperature.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

Publications (2)

1
Association with cullin partners protects ROC proteins from proteasome-dependent degradation. Ohta T, Michel JJ, Xiong Y. Oncogene. 1999 18:6758-66. [PubMed:10597284]
2
Activation of UBC5 ubiquitin-conjugating enzyme by the RING finger of ROC1 and assembly of active ubiquitin ligases by all cullins. Furukawa M, Ohta T, Xiong Y. The Journal of biological chemistry. 2002 277:15758-65. [PubMed:11861641]

Customer Reviews (0)


Requested From: 
Date Requested: 6/21/2018

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