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Anti-AKR1C4 / Chlordecone Reductase Antibody (aa2-14) IHC-plus™ LS-B2759

Note: This antibody replaces LS-C54478, LS-C68878

Ordering

Wt. Vol. Conc. Price
50 µg - 1 mg/ml $395
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
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Orders@LSBio.com
 

Most Popular AKR1C4 / Chlordecone Reductase Antibodies

Anti-AKR1C4 / Chlordecone Reductase Antibody (aa2-14) IHC-plus™ LS-B2759
Goat Polyclonal to Human AKR1C4 / Chlordecone Reductase
Human
IHC - Paraffin, Western blot, ELISA
Unconjugated
Immunohistochemistry Image
Anti-AKR1C4 / Chlordecone Reductase Antibody (clone 2C11) IHC-plus™ LS-B5390
Mouse Monoclonal [clone 2C11] (IgG1,k) to Human AKR1C4 / Chlordecone Reductase
Human
IHC - Paraffin, Immunofluorescence, Western blot, ELISA
Unconjugated
Immunohistochemistry Image
Anti-AKR1C4 / Chlordecone Reductase Antibody (aa10-39, Biotin) LS-C212651
Rabbit Polyclonal (IgG) to Human AKR1C4 / Chlordecone Reductase
Human
Western blot, ELISA
Biotin Conjugated

100% Guaranteed 100% Guaranteed
Goat Polyclonal to Human AKR1C4 / Chlordecone Reductase
Human
IHC - Paraffin, Western blot, ELISA
Unconjugated

Details

Human AKR1C4 / Chlordecone Reductase
Goat
Human (tested or 100% immunogen sequence identity)
Monkey, Bovine (at least 90% immunogen sequence identity)
Polyclonal
Unconjugated
Immunoaffinity purified
Unmodified

Applications

  • IHC - Paraffin (2.5 µg/ml)
  • Western blot (0.1 - 0.3 µg/ml)
  • ELISA (1:4000)

Specificity and Use

AKR1C4 / Chlordecone Reductase antibody was raised against synthetic peptide DPKYQRVELNDGH-C from the N-terminus of human AKR1C4 (NP_001809.2). Percent identity by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey, Bovine (92%); Marmoset, Horse (85%).
LS-E26091 - Lyophilized - 100 µg - $145.00
aa2-14
Human AKR1C4. This antibody may cross-react with AKR1C1
Immunohistochemistry: LS-B2759 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B2759 was determined to be 2.5 ug/ml.

Packaging

Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Store at -20°C. Minimize freezing and thawing.
For research use only.

About AKR1C4 / Chlordecone Reductase

P17516 NM_001818 NP_001809.3

AKR1C4 Antibody, 3-alpha-HSD Antibody, 3-alpha-HSD1 Antibody, Chlordecone reductase Antibody, CDR Antibody, CHDR Antibody, DD-4 Antibody, Dihydrodiol dehydrogenase 4 Antibody, C11 Antibody, DD4 Antibody, HAKRA Antibody

Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.

Immunohistochemistry

Immunohistochemistry
Anti-AKR1C4 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2759 concentration 5 ug/ml.

Western blot

Western blot
Antibody (0.1 ug/ml) staining of human liver lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Requested From: United States
Date Requested: 12/8/2016

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