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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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ADRB3 Antibody (N‑Terminus) IHC‑plus™ LS‑A4198
ADRB3 antibody LS-A4198 is an unconjugated rabbit polyclonal antibody to ADRB3 from human and rat. Validated for IHC. Tested on 20 paraffin-embedded human tissues. Cited in 4 publications.
Catalog
Size
Price
LS-A4198-50
50 µg (1 mg/ml)
$425
In Stock for Immediate Shipment

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Product Description

ADRB3 antibody LS-A4198 is an unconjugated rabbit polyclonal antibody to ADRB3 from human and rat. Validated for IHC. Tested on 20 paraffin-embedded human tissues. Cited in 4 publications.
About ADRB3
The Beta-3 Adrenoceptor (ADRB3) is an Adrenergic Receptor that stimulates lipolysis and increases fatty acids in the blood. Stimulation of the beta-3 adrenoceptor leads to lipolysis in white adipocytes and nonshivering thermogenesis in brown fat. The beta-3 adrenoceptor has also been suggested to affect the physiological control of cardiac and vascular contractility; beta-3 adrenoceptor stimulation decreases cardiac contractility through activation of a nitric oxide synthase pathway. P13945 NM_000025 NP_000016.1

ADRB3 Antibody, Adrenoceptor beta 3 Antibody, ADRB3R Antibody, Adrenaline beta 3 receptor Antibody, Adrenergic, beta-3-, receptor Antibody, Beta-3 adrenergic receptor Antibody, B3AR Antibody, Beta-3 adrenoceptor Antibody, Beta3-AR Antibody, Beta-3 adrenoreceptor Antibody, BETA3AR Antibody


Specifications

Target
Human ADRB3
Host
Rabbit
Reactivity
Human, Rat (tested or 100% immunogen sequence identity)
Predicted
Guinea pig (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (10 - 15 µg/ml)
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
ADRB3 antibody was raised against synthetic 20 amino acid peptide from N-terminal extracellular domain of human ADRB3. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon (95%); Guinea pig (90%); Monkey, Elephant, Rabbit (85%); Sheep, Goat, Hamster, Cat, Bovine, Horse (80%).
Blocking Peptide
LS-E28912 - Liquid - 50 µg 1 mg/ml - $145.00
Immunizing peptide used to generate LS-A4198. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
N-Terminus
Specificity
Human ADRB3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

Publications (4)

1
Effects of beta3-adrenergic receptor activation on rat urinary bladder hyperactivity induced by ovariectomy. Kullmann FA, Limberg BJ, Artim DE, Shah M, Downs TR, Contract D, Wos J, Rosenbaum JS, de Groat WC. The Journal of pharmacology and experimental therapeutics. 2009 330:704-17. (IHC-P; Rat) [Full Text Article] [PubMed:19515967] [PMC:PMC2729793]
2
ß-Adrenergic receptor subtype expression in myocyte and non-myocyte cells in human female bladder. Limberg BJ, Andersson KE, Aura Kullmann F, Burmer G, de Groat WC, Rosenbaum JS. Cell and tissue research. 2011 317:107-16. (ICC, IHC-P; Human) [Full Text Article] [PubMed:20953633] [PMC:PMC3113530]
3
Urothelial beta-3 adrenergic receptors in the rat bladder. Kullmann FA, Downs TR, Artim DE, Limberg BJ, Shah M, Contract D, de Groat WC, Rosenbaum JS. Neurourology and urodynamics. 2011 30:144-50. (IHC-P; Rat) [Full Text Article] [PubMed:21046653] [PMC:PMC3395322]
4
Expression and functional role of beta 3 -adrenoceptors in the human ureter. Matsumoto R, Otsuka A, Suzuki T, Shinbo H, Mizuno T, Kurita Y, Mugiya S, Ozono S. International journal of urology : official journal of the Japanese Urological Association. Oct;20:1007-14. [Full Text Article] [PubMed:23360304]
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Customer Reviews (0)


Images

Immunohistochemistry

Anti-ADRB3 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ADRB3 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-ADRB3 antibody LS-A4198 IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ADRB3 antibody LS-A4198 IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-ADRB3 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ADRB3 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-ADRB3 antibody LS-A4198 IHC of human adipose. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ADRB3 antibody LS-A4198 IHC of human adipose. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunocytochemistry

Anti-ADRB3 antibody LS-A4198 IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ADRB3 antibody LS-A4198 IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-ADRB3 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ADRB3 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-ADRB3 antibody LS-A4198 IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ADRB3 antibody LS-A4198 IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-ADRB3 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ADRB3 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-ADRB3 antibody LS-A4198 IHC of human adipose. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ADRB3 antibody LS-A4198 IHC of human adipose. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunocytochemistry

Anti-ADRB3 antibody LS-A4198 IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ADRB3 antibody LS-A4198 IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-ADRB3 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ADRB3 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-ADRB3 antibody LS-A4198 IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ADRB3 antibody LS-A4198 IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-ADRB3 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ADRB3 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-ADRB3 antibody LS-A4198 IHC of human adipose. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ADRB3 antibody LS-A4198 IHC of human adipose. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunocytochemistry

Anti-ADRB3 antibody LS-A4198 IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ADRB3 antibody LS-A4198 IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-ADRB3 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ADRB3 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-ADRB3 antibody LS-A4198 IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ADRB3 antibody LS-A4198 IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-ADRB3 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ADRB3 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-ADRB3 antibody LS-A4198 IHC of human adipose. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ADRB3 antibody LS-A4198 IHC of human adipose. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunocytochemistry

Anti-ADRB3 antibody LS-A4198 IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ADRB3 antibody LS-A4198 IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Requested From: United States
Date Requested: 8/17/2018

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