Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
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order histories, retained contact details for faster checkout, review submissions, and special promotions.
Human, Mouse (tested or 100% immunogen sequence identity)
Monkey (at least 90% immunogen sequence identity)
Polyclonal
Unconjugated
Protein G purified
Unmodified
Applications
Western blot (1 - 3 µg/ml)
Specificity and Use
AcPL / IL18RAP antibody was raised against a synthetic peptide corresponding to amino acids 86-100 QQPSNGDPLEDIRKS of human IL-18 Receptor accessory protein/IL-18 RA/AcPL. Percent identity by BLAST analysis: Human (100%); Chimpanzee, Gorilla, Orangutan, Monkey, Marmoset (93%); Gibbon (87%); Mouse, Rat (53%).
aa50-100
A portion of amino acids 50-100 of human AcPL was used as the immunogen.
AcPL / IL18RAP is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy.