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Anti-ABCC6 / MRP6 Antibody (clone M6II-31) LS-C134868

Ordering

Wt. Vol. Conc. Price
- 1000 µl - $325
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular ABCC6 / MRP6 Antibodies

Anti-ABCC6 / MRP6 Antibody (aa764-964, clone M6II-21) LS-C124155
Rat Monoclonal [clone M6II-21] (IgG1) to Human ABCC6 / MRP6
Human
IHC - Frozen, ICC, Western blot
Unconjugated
Anti-ABCC6 / MRP6 Antibody (Internal, clone EPR8342) IHC-plus™ LS-B8479
Rabbit Monoclonal [clone EPR8342] (IgG) to Human ABCC6 / MRP6
Human
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Rat Monoclonal [clone M6II-31] (IgG2a) to Human ABCC6 / MRP6
Human
IHC - Paraffin, IHC - Frozen, Western blot, Flow Cytometry
Unconjugated

Details

Human ABCC6 / MRP6
Rat
Human (tested or 100% immunogen sequence identity)
IgG2a Monoclonal [M6II-31]
Unconjugated
Tissue culture supernatant
Unmodified

Applications

  • IHC - Paraffin
  • IHC - Frozen
  • Western blot
  • Flow Cytometry

Specificity and Use

M6II-31 reacts with MRP6, a 190-200 kD transmembrane protein that is related to the multidrug resistance related protein MRP. Mutations in the MRP6 gene are responsible for the connective tissue disorder Pseudoxanthoma elasticum (PXE). M6II-31 was raised against a bacterial fusion protein of human MRP6, containing amino acids 764-964, spanning the putative 12th transmembrane region as well as predicted internal and external regions of the protein. M6II-7 did not cross-react with the human MDR1, MRP1, MRP2, MRP3, MRP4, MRP5 gene products.
M6II-31 can be used to detect human MRP6 in cells and tissues. Immunocytochemistry: use 1:20-50 dilution on acetone fixed cytospin preparations. For immunohistochemistry: M6II-31 (use 1:20-50) on acetone fixed frozen sections can be followed by incubation with rabbit anti-rat IgG (1:25, Dako) and an APAAP complex (1:50, Dako). M6II-31 can be used on formaldehyde-fixed paraffin-embedded human tissues, after pretreatment with 0.01 M citric acid (pH 6.0) in distilled water at 100 C for 10 minutes. After incubation of M6II-31 (use 1:20) and washing, slides can be incubated with biotinylated rabbit anti-rat IgG (1:100, Jackson, West Grove) and streptavidin conjugated to horseradish peroxidase (1:500, Zymed, San Francisco, CA). Flow cytometry: optimal conditions still to be defined. Western blotting: use 1:20-50 dilution and anti-rat-HRP.

Packaging

Tissue culture supernatant (serum-free), 0.7% BSA, 0.1% sodium azide
Store at -20°C.
For research use only.

About ABCC6 / MRP6

O95255 NM_001171 NP_001162.4

ABCC6 Antibody, ABC34 Antibody, EST349056 Antibody, MLP1 Antibody, MOAT-E Antibody, MRP6 Antibody, MOATE Antibody, URG7 Antibody, PXE1 Antibody, ARA Antibody, GACI2 Antibody, Pseudoxanthoma elasticum Antibody, PXE Antibody

ABCC6 / MRP6 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum.

Requested From: United States
Date Requested: 12/8/2016

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