LSBio The Immunohistochemistry Antibody Company
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  • Immunohistochemistry Services

  • Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

  • TCR Screening Services

  • Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
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LifeSpan's Tissue Resources (for use in Contract Research Services only)

LifeSpan has established extensive tissue resources in order to support its contract research services (tissues are not for sale as independent products). These resources include a massive internal collection of over 2 million tissue specimens, normal and diseased tissue microarrays, and a network of commercial and academic partners that can fulfill custom tissue requests. To ensure availability of the most commonly requested tissues, LifeSpan has prioritized its tissue procurement efforts on the most prominent Therapeutic Area Tissues, such as CNS, metabolic disorders, and inflammatory disease. By combining these resources with expertise in pathology, tissue quality control, and immunohistochemistry, LifeSpan can provide full service localization profiling, without requiring the client to source difficult to obtain reagents.


LifeSpan's In-House Tissue Bank

With more than 2 million formalin-fixed paraffin-embedded samples, LifeSpan has one of the largest on-site collections of normal and diseased human tissues in the industry. This resource provides LifeSpan with the range of samples necessary to pinpoint gene expression specific to a given disease and stage. LifeSpan's tissue bank is comprised of tissues from all major organ systems, including samples representing more than 1,500 diagnostic categories. Specimens are in the form of both formalin-fixed paraffin-embedded specimens as well as fresh frozen. In addition to human tissues, LifeSpan has gathered a comprehensive collection of normal primate specimens, as well as other specimens from common animal models such as mouse, rat, and dog.


Therapeutic Area Tissues

By focusing our efforts on maintaining an inventory of major therapeutic area tissues, LifeSpan ensures its ability to quickly satisfy the needs of its drug discovery clients. For each therapeutic area, the following lists of commonly requested normal and diseased tissues have been defined. LifeSpan endeavors to maintain an inventory of these tissues, or has established relationships through which they can be obtained. These materials are available for inclusion in contract research studies but are not representative of the entire LifeSpan collection. Many other tissue types and diseases are also available from LifeSpan's vast tissue repository.

Normal Tissues

Single Specimens and TMAs

  • All major organs
Human Body

Toxicology Center

Single Specimens and TMAs

  • Mouse, Rat, Dog, Cynomolgus

Neurological Disease Center

Normal Specimens

  • All major brain regions
  • Mapped hippocampus, hypothalamus, amygdala

Diseased Specimens

  • Alzheimer's disease
  • Parkinson's disease
  • Multiple sclerosis
  • ALS
  • Glioblastoma, astrocytoma
  • Infarct

Inflammatory Disease Center

Single specimens
Inflammatory Disease Screens
Differential Expression Panels

  • Ulcerative Colitis Panel
  • Crohn's Disease Panel
  • Asthma Panel
  • COPD Panel
  • Allergic Rhinitis Panel
  • BPH Panel
  • Skin Disorder Panel
  • Rheumatoid Arthritis Panel
  • Lung Disease Panel
     
 

Oncology Disease Center

Single specimens and TMAs representing 6 major cancer types

  • Breast (IDC), Colon, Lung (NSC), Prostate, Pancreas, and Ovary
Focused Study Arrays and Panels
  • Multi-cancer screening TMAs
  • Single Cancer Prevalence TMAs (N=50)
  • Differential Expression Screens
  • Progression Panels

Cardiovascular Disease Center

Single Specimens
Screens and panels

  • Atherosclerosis Screen 1 (Coronary artery disease)
  • Atherosclerosis Differential Expression Panel
  • Heart Failure Differential Expression Panel
  • Human Cardiac Survey
  • Canine Cardiac Survey
     
 

Metabolic Disease Center

Single Specimens and Panels for:

  • Type II Diabetes Screen
  • Obesity Screen
  • Hypertension Screen

Tissue Cross-Reactivity Center

32+ Frozen Normal Tissue Types
(each from 3 non-related individuals)

  • Cynomolgus Tissue Screen
  • Human Tissue Screen
     
 

 



Tissue Microarrays

TMAsTissue microarrays (TMAs) are a cost-effective and convenient resource that enables researchers to simultaneously study protein localization patterns in large numbers of normal and diseased tissues. LifeSpan can supply TMAs for use in LSBio Immunohistochemistry Studies. When using tissue microarrays, two critical factors need to be considered:

  • Will the specimen's size be sufficient to answer the biological question?
  • Are the elements of adequate quality for use in a study?

When designing a study, LifeSpan ensures that the tissues used will be adequate to answer the biological question being asked. For example, cancer TMAs would be insufficient when studying the angiogenesis associated with tumor development. When arrays are used in a study they are rigorously tested to ensure that each specimen was fixed appropriately, exhibits the defined pathology, and is antigenic when tested in immunohistochemistry using control antibodies. 

 


Supplied Tissues

LifeSpan often conducts contract research studies using tissue materials supplied by the client or procured from other commercial resources. Studies are often strengthened by the inclusion of over-expressing cell lines (when available) as antibody characterization positive controls. Human tissues, non-human tissues, and cell lines can be supplied in fixative for paraffin embedding or as prepared paraffin blocks.

An increasing number of TMAs have become available commercially, however, quality may vary from vendor to vendor. These reagents can be powerful tools for localization profiling, but care must be taken during interpretation to ensure accuracy of results. LifeSpan welcomes the use of such commercial tissue resources in its contract research studies and offers its extensive molecular pathology expertise to ensure that the quality of these materials is such that we would be able to provide reliable immunohistological data. 


Tissue Procurement Services

In the event that specific tissue specimens are not immediately available from LifeSpan's internal tissue bank, Lifespan has the ability to procure these materials on a prospective basis. The relationships that LifeSpan has developed with external resources allows for timely tissue procurement, often at a preferred price. Tissue procurement is available only in conjunction with the execution of contract research services.


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