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FZD1 / Frizzled 1
frizzled class receptor 1
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B.
| Gene Name: | frizzled class receptor 1 |
| Family/Subfamily: | GPCR , Frizzled |
| Synonyms: | FZD1, Chfz-1, Fz1, Frizzled 1, Fz receptor 1, HFz1, Frizzled homolog 1, Fz-1, FzE1, Rfz1, Xfrizzled-1, Wnt receptor, Dfrizzled-1, Frizzled family receptor 1, Frizzled-1 |
| Target Sequences: | NM_003505 NP_003496.1 Q9UP38 |
Publications (2)
1
Frizzled-1 receptor regulates adult hippocampal neurogenesis. Mardones MD, Andaur GA, Varas-Godoy M, Henriquez JF, Salech F, Behrens MI, Couve A, Inestrosa NC, Varela-Nallar L. Molecular brain. 2016 9:29. (ICC; Mouse)
[Full Text Article]
[PubMed:26980182]
[PMC:PMC4791773]
Related Antibodies: LS-C6893.
2
Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate. Arpan Parichha , Varun Suresh , Mallika Chatterjee, Aditya Kshirsagar, Lihi Ben-Reuven, Tsviya Olender, M Mark Taketo, Velena Radosevic, Mihaela Bobic-Rasonja, Sara Trnski, Michael J Holtzman, Nataša Jovanov-Milosevic, Orly Reiner, Shubha Tole. Nature communications. 2022 February;13:633. [Full Text Article]
[PubMed:35110543]
[PMC:PMC8810795]
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FZD1 / Frizzled 1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Horse, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
FZD1 / Frizzled 1 Goat anti-Mouse Polyclonal Antibody
Mouse
ELISA, ICC, IHC, WB
Unconjugated
100 µg/$930
FZD1 / Frizzled 1 Rabbit anti-Human Polyclonal (aa6-55) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
FZD1 / Frizzled 1 Rabbit anti-Human Polyclonal (aa367-396) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
FZD1 / Frizzled 1 Rat anti-Mouse Monoclonal Antibody
Mouse, Human
ELISA, Flo, WB
Unconjugated
100 µg/$930
FZD1 / Frizzled 1 Goat anti-Mouse Polyclonal (Biotin) Antibody
Mouse
IHC, WB
Biotin Conjugated
50 µg/$973
FZD1 / Frizzled 1 Rabbit anti-Mouse Polyclonal (aa112-317) Antibody
Mouse
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
FZD1 / Frizzled 1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
FZD1 / Frizzled 1 Rat anti-Mouse Monoclonal (Extracellular Domain) (Biotin) Antibody
Mouse, Human
Flo, ICC, WB
Biotin Conjugated
100 µg/$848
FZD1 / Frizzled 1 Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, IHC, IHC-P
Unconjugated
100 µl/$412
FZD1 / Frizzled 1 Rabbit anti-Human Polyclonal (30-110 aa, N-terminal) Antibody
Human
ELISA, IF, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
FZD1 / Frizzled 1 Rabbit anti-Human Polyclonal Antibody
Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
FZD1 / Frizzled 1 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µg/$575
FZD1 / Frizzled 1 Rabbit anti-Human Polyclonal (aa369-400) Antibody
Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
FZD1 / Frizzled 1 Rat anti-Mouse Monoclonal (Extracellular Domain) Antibody
Mouse
ELISA, WB
Unconjugated
500 µg/$1,079
FZD1 / Frizzled 1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
FZD1 / Frizzled 1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
FZD1 / Frizzled 1 Rabbit anti-Human Polyclonal (aa16-65) Antibody
Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
FZD1 / Frizzled 1 Rabbit anti-Human Polyclonal (aa15-64) Antibody
Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
FZD1 / Frizzled 1 Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA
Unconjugated
100 µl/$412
FZD1 / Frizzled 1 Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA
Unconjugated
100 µl/$412
FZD1 / Frizzled 1 Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA
Unconjugated
100 µl/$375; 200 µl/$473; 400 µl/$648
FZD1 / Frizzled 1 Rabbit anti-Human Polyclonal (aa504-533) Antibody
Human
WB
Unconjugated
400 µl/$393
FZD1 / Frizzled 1 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µl/$408
FZD1 / Frizzled 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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